Guardian ancestry: Fly p53 and damage-inducible apoptosis

W. Nordstrom, J. M. Abrams

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The tumor suppressor, p53, is among the most commonly mutated genes in human cancers. Recent reports describe shared and divergent properties of a Drosophila p53 homolog Dmp53. Like its mammalian counterpart, Dmp53 also functions in damage-induced cell death. In this model system, the apoptosis activator reaper has emerged as an important target gene. Together with the wealth of genomic data available in Drosophila, continued studies on Dmp53 promise new insights into the regulation and function of this important gene family.

Original languageEnglish (US)
Pages (from-to)1035-1038
Number of pages4
JournalCell Death and Differentiation
Issue number11
StatePublished - 2000


  • Apoptosis
  • Drosophila
  • P53

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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