Guidance on the conversion of the Chinese versions of the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR) and the Montgomery-Asberg Scale (C-MADRS) in Chinese patients with major depression

Jia Liu, Yu Tao Xiang, Hui Lei, Qian Wang, Gang Wang, Gabor S. Ungvari, David W. Morris, Xiong Zhao Zhu, Kelly Y C Lai, Bao Liang Zhong, Samuel Y S Wong, Ling Zhang, Qinge Zhang, Yu Chuan Zou, Le Xiao, Qian Zhao, Yang Li, Jiang Wu, Guo Fu Zhang, Helen F K Chiu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background The 16-item Quick Inventory of Depressive Symptomatology-Self- Report (QIDS-SR) is a newly introduced screening tool, while the Montgomery-Asberg Scale (MADRS) is commonly used in research and clinical practice in China. Converting the total scores between the two instruments could facilitate the comparison of different studies. Methods This study included 1164 patients with major depressive disorder (MDD). The diagnosis was established using the Mini International Neuropsychiatric Interview (MINI). The severity of depressive symptoms was assessed with the Chinese versions of MADRS (C-MADRS) and QIDS-SR (C-QIDS-SR) at baseline and 6 weeks later (exit point). Total scores of both scales were converted using Item Response Theory (IRT) analysis. Results At baseline, the C-MADRS and C-QIDS-SR were not unifactorial, therefore the conversion between them could not be performed. At exit, the C-MADRS and C-QIDS-SR were unifactorial, meeting the unidimensionality assumption of the IRT approach. Depression severity thresholds for the QIDS-SR are suggested as 6-10 for mild, 11-15 for moderate, 16-20 for severe, 21+ for very severe depression and ≤5 for remission (www.ids-qids.org). Based on the results of this study, the corresponding C-MADRS thresholds are 9-17 for mild, 18-24 for moderate, 25-33 for severe, 34+ for very severe depression and ≤7 or 8 (7.5) for remission. Conclusions The conversion of C-QIDS-SR and C-MADRS total scores would help researchers understand findings across different studies using these scales.

Original languageEnglish (US)
Pages (from-to)530-533
Number of pages4
JournalJournal of affective disorders
Volume152-154
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • China
  • Conversion
  • Major depressive disorder
  • Scale
  • Self-report

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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