Guided-mode resonance sensors for rapid medical diagnostic testing applications

D. Wawro, Y. Ding, S. Gimlin, S. Zimmerman, C. Kearney, K. Pawlowski, R. Magnusson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

A new tag-free photonic resonance concept occurring on subwavelength waveguide gratings is applied for rapid medical testing applications. These high-resolution sensors operate in real time while being sensitive to a wide variety of analytes, including microbials. This method does not require extensive processing steps, thus simplifying assay tests and enabling a rapid response (less than 30 minutes is possible). In this work, a sensor system that uses a single, fixedwavelength source with a shaped input wavefront to auto-scan in angle has been developed. As binding events occur at the sensor surface, shifts in a resonance reflection peak (or a corresponding transmission minimum) are tracked as a function of incident angle. The amount of angular shift is correlated to the quantity of analyte in the test sample. Due to inherent polarization diversity, two narrow peaks shift their positions on the sensor surface when a bioreaction occurs, thereby providing cross-referenced data. The sensor system connects to portable interfaces for data acquisition and analysis by dedicated software codes. A portable guided-mode resonance sensor system prototype has been developed. Its performance for the detection of the microbial S. aureus in buffer and rat serum is presented in this paper.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7173
DOIs
StatePublished - 2009
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX - San Jose, CA, United States
Duration: Jan 24 2009Jan 25 2009

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX
CountryUnited States
CitySan Jose, CA
Period1/24/091/25/09

Fingerprint

Optics and Photonics
Buffers
Software
sensors
Sensors
Testing
Serum
shift
Wavefronts
serums
Photonics
rats
data acquisition
Rats
Assays
Data acquisition
Waveguides
buffers
prototypes
gratings

Keywords

  • Bacteria detection
  • Biosensor
  • Guided-mode resonance
  • Medical diagnostics
  • Microbial sensor

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Wawro, D., Ding, Y., Gimlin, S., Zimmerman, S., Kearney, C., Pawlowski, K., & Magnusson, R. (2009). Guided-mode resonance sensors for rapid medical diagnostic testing applications. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7173). [717303] https://doi.org/10.1117/12.809523

Guided-mode resonance sensors for rapid medical diagnostic testing applications. / Wawro, D.; Ding, Y.; Gimlin, S.; Zimmerman, S.; Kearney, C.; Pawlowski, K.; Magnusson, R.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7173 2009. 717303.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wawro, D, Ding, Y, Gimlin, S, Zimmerman, S, Kearney, C, Pawlowski, K & Magnusson, R 2009, Guided-mode resonance sensors for rapid medical diagnostic testing applications. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7173, 717303, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX, San Jose, CA, United States, 1/24/09. https://doi.org/10.1117/12.809523
Wawro D, Ding Y, Gimlin S, Zimmerman S, Kearney C, Pawlowski K et al. Guided-mode resonance sensors for rapid medical diagnostic testing applications. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7173. 2009. 717303 https://doi.org/10.1117/12.809523
Wawro, D. ; Ding, Y. ; Gimlin, S. ; Zimmerman, S. ; Kearney, C. ; Pawlowski, K. ; Magnusson, R. / Guided-mode resonance sensors for rapid medical diagnostic testing applications. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7173 2009.
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