Guidelines for Translational Research in Heart Failure

Enrique Lara-Pezzi, Philippe Menasché, Jean Hugues Trouvin, Lina Badimón, John P A Ioannidis, Joseph C. Wu, Joseph A Hill, Walter J. Koch, Albert F. De Felice, Peter de Waele, Valérie Steenwinckel, Roger J. Hajjar, Andreas M. Zeiher

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Heart failure (HF) remains a major cause of death and hospitalization worldwide. Despite medical advances, the prognosis of HF remains poor and new therapeutic approaches are urgently needed. The development of new therapies for HF is hindered by inappropriate or incomplete preclinical studies. In these guidelines, we present a number of recommendations to enhance similarity between HF animal models and the human condition in order to reduce the chances of failure in subsequent clinical trials. We propose different approaches to address safety as well as efficacy of new therapeutic products. We also propose that good practice rules are followed from the outset so that the chances of eventual approval by regulatory agencies increase. We hope that these guidelines will help improve the translation of results from animal models to humans and thereby contribute to more successful clinical trials and development of new therapies for HF.

Original languageEnglish (US)
Pages (from-to)3-22
Number of pages20
JournalJournal of cardiovascular translational research
Volume9
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Animal models
  • Clinical trials
  • Good laboratory practice
  • Guidelines
  • Heart failure
  • Induced pluripotent stem cells
  • New therapies
  • Preclinical studies
  • Toxicity

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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  • Cite this

    Lara-Pezzi, E., Menasché, P., Trouvin, J. H., Badimón, L., Ioannidis, J. P. A., Wu, J. C., Hill, J. A., Koch, W. J., De Felice, A. F., de Waele, P., Steenwinckel, V., Hajjar, R. J., & Zeiher, A. M. (2015). Guidelines for Translational Research in Heart Failure. Journal of cardiovascular translational research, 9(1), 3-22. https://doi.org/10.1007/s12265-015-9606-8