HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

Stephen T. Chambers, David Murdoch, Arthur Morris, David Holland, Paul Pappas, Manel Almela, Nuria Fernández-Hidalgo, Benito Almirante, Emilio Bouza, Davide Forno, Ana del Rio, Margaret M. Hannan, John Harkness, Zeina A. Kanafani, Tahaniyat Lalani, Selwyn Lang, Nigel Raymond, Kerry Read, Tatiana Vinogradova, Christopher W. WoodsDannah Wray, G. Ralph Corey, Vivian H. Chu, Liliana Clara, Marisa Sanchez, Francisco Nacinovich, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, José Casabé, Claudia Cortes, Javier Altclas, Sanatorio Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Lito Papanicolas, Damon Eisen, Leeanne Grigg, Alan Street, Tony Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Phillip Jones, Suzanne Ryan, Phillip Jones, Suzanne Ryan, Phillip Jones, Jeffrey Post, Porl Reinbott, Suzanne Ryan, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Claudio Querido Fortes, Auristela de Oliveira Ramos, Giovanna Ferraiuoli, Wilma Golebiovski, Cristiane Lamas, Marisa Santos, Clara Weksler, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, M. Cereceda, Alberto Fica, Rodrigo Montagna Mella, Bruno Barsic, Suzana Bukovski, Vladimir Krajinovic, Ana Pangercic, Igor Rudez, Josip Vincelj, Tomas Freiberger, Jiri Pol, Barbora Zaloudikova, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Hussien Rizk, Neijla Aissa, Corentine Alauzet, Francois Alla, Catherine Campagnac, Thanh Doco-Lecompte, Christine Selton-Suty, Jean Paul Casalta, Pierre Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, Francois Delahaye, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Christian Michelet, Matthieu Revest, Pierre Tattevin, Jérémie Violette, Florent Chevalier, Antoine Jeu, Dan M D Rusinaru, Claire Sorel, Christophe Tribouilloy, Yvette Bernard, Catherine Chirouze, Bruno Hoen, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Christoph Naber, Carl Neuerburg, Sofia Athanasia, Efthymia Giannitsioti, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Margaret Hannan, John Hurley, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Ethan Rubinstein, Jacob Strahilevitz, Marie Françoise Tripodi, Roberta Casillo, Susanna Cuccurullo, Giovanni Dialetto, Emanuele Durante-Mangoni, Mattucci Irene, Enrico Ragone, Riccardo Utili, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Alessandro Tebini, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Tania Baban, Zeina Kanafani, Souha S. Kanj, Jad Sfeir, Mohamad Yasmine, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T M van der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David R. Murdoch, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O. M. Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Luh Nah Lum, Ru San Tan, Tatjana Lejko-Zupanc, Mateja Logar, Manica Mueller-Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manuel Almela, Yolanda Armero, Manuel Azqueta, Ximena Castañeda, Carlos Cervera, Ana del Rio, Carlos Falces, Cristina Garcia-de-la-Maria, Guillermina Fita, Jose M. Gatell, Francesc Marco, Carlos A. Mestres, José M. Miró, Asuncion Moreno, Salvador Ninot, Carlos Paré, Joan Pericas, Jose Ramirez, Irene Rovira, Marta Sitges, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Emilio Bouza, Miguel Angel Garcia Fernández, Victor Gonzalez-Ramallo, Mercedes Marín, Patricia Muñoz, Miguel Pedromingo, Jorge Roda, Marta Rodríguez-Créixems, Jorge Solis, Benito Almirante, Nuria Fernandez-Hidalgo, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg-Martin, Orathai Pachirat, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol Kauffman, Roger Bedimo, Vivian H. Chu, G. Ralph Corey, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Vance G. Fowler, Thomas Holland, Tahaniyat Lalani, Daniel Mudrick, Zaniab Samad, Daniel Sexton, Martin Stryjewski, Andrew Wang, Christopher W. Woods, Stamatios Lerakis, Robert Cantey, Lisa Steed, Dannah Wray, Stuart A. Dickerman, Hector Bonilla, Joseph DiPersio, Sara Jane Salstrom, John Baddley, Mukesh Patel, Gail Peterson, Amy Stancoven, Luis Afonso, Theresa Kulman, Donald Levine, Michael Rybak, Christopher H. Cabell, Khaula Baloch, Vivian H. Chu, G. Ralph Corey, Christy C. Dixon, Vance G. Fowler, Tina Harding, Marian Jones-Richmond, Paul Pappas, Lawrence P. Park, Thomas Redick, Judy Stafford, Kevin Anstrom, Eugene Athan, Arnold S. Bayer, Christopher H. Cabell, Vivian H. Chu, Bruno Hoen, A. W. Karchmer, David R. Murdoch, Daniel J. Sexton, Andrew Wang, Arnold S. Bayer, Christopher H. Cabell, Vivian Chu, David T. Durack, Susannah Eykyn, Bruno Hoen, Phillipe Moreillon, Lars Olaison, Didier Raoult, Ethan Rubinstein

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.

Original languageEnglish (US)
Article numbere63181
JournalPLoS One
Volume8
Issue number5
DOIs
StatePublished - May 17 2013

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endocarditis
Prosthetics
Endocarditis
Pathogens
Surgery
stroke
Stroke
Cardiobacterium hominis
Kingella
Aggregatibacter
Eikenella corrodens
Cardiobacterium
Haemophilus
pathogens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chambers, S. T., Murdoch, D., Morris, A., Holland, D., Pappas, P., Almela, M., ... Rubinstein, E. (2013). HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort. PLoS One, 8(5), [e63181]. https://doi.org/10.1371/journal.pone.0063181

HACEK Infective Endocarditis : Characteristics and Outcomes from a Large, Multi-National Cohort. / Chambers, Stephen T.; Murdoch, David; Morris, Arthur; Holland, David; Pappas, Paul; Almela, Manel; Fernández-Hidalgo, Nuria; Almirante, Benito; Bouza, Emilio; Forno, Davide; Rio, Ana del; Hannan, Margaret M.; Harkness, John; Kanafani, Zeina A.; Lalani, Tahaniyat; Lang, Selwyn; Raymond, Nigel; Read, Kerry; Vinogradova, Tatiana; Woods, Christopher W.; Wray, Dannah; Corey, G. Ralph; Chu, Vivian H.; Clara, Liliana; Sanchez, Marisa; Nacinovich, Francisco; Oses, Pablo Fernandez; Ronderos, Ricardo; Sucari, Adriana; Thierer, Jorge; Casabé, José; Cortes, Claudia; Altclas, Javier; Silvia Kogan, Sanatorio; Spelman, Denis; Athan, Eugene; Harris, Owen; Kennedy, Karina; Tan, Ren; Gordon, David; Papanicolas, Lito; Eisen, Damon; Grigg, Leeanne; Street, Alan; Korman, Tony; Kotsanas, Despina; Dever, Robyn; Jones, Phillip; Konecny, Pam; Lawrence, Richard; Rees, David; Ryan, Suzanne; Feneley, Michael P.; Harkness, John; Jones, Phillip; Ryan, Suzanne; Jones, Phillip; Ryan, Suzanne; Jones, Phillip; Post, Jeffrey; Reinbott, Porl; Ryan, Suzanne; Gattringer, Rainer; Wiesbauer, Franz; Andrade, Adriana Ribas; de Brito, Ana Cláudia Passos; Guimarães, Armenio Costa; Grinberg, Max; Mansur, Alfredo José; Siciliano, Rinaldo Focaccia; Strabelli, Tania Mara Varejao; Vieira, Marcelo Luiz Campos; de Medeiros Tranchesi, Regina Aparecida; Paiva, Marcelo Goulart; Fortes, Claudio Querido; de Oliveira Ramos, Auristela; Ferraiuoli, Giovanna; Golebiovski, Wilma; Lamas, Cristiane; Santos, Marisa; Weksler, Clara; Karlowsky, James A.; Keynan, Yoav; Morris, Andrew M.; Rubinstein, Ethan; Jones, Sandra Braun; Garcia, Patricia; Cereceda, M.; Fica, Alberto; Mella, Rodrigo Montagna; Barsic, Bruno; Bukovski, Suzana; Krajinovic, Vladimir; Pangercic, Ana; Rudez, Igor; Vincelj, Josip; Freiberger, Tomas; Pol, Jiri; Zaloudikova, Barbora; Ashour, Zainab; Kholy, Amani El; Mishaal, Marwa; Rizk, Hussien; Aissa, Neijla; Alauzet, Corentine; Alla, Francois; Campagnac, Catherine; Doco-Lecompte, Thanh; Selton-Suty, Christine; Casalta, Jean Paul; Fournier, Pierre Edouard; Habib, Gilbert; Raoult, Didier; Thuny, Franck; Delahaye, Francois; Delahaye, Armelle; Vandenesch, Francois; Donal, Erwan; Donnio, Pierre Yves; Michelet, Christian; Revest, Matthieu; Tattevin, Pierre; Violette, Jérémie; Chevalier, Florent; Jeu, Antoine; Rusinaru, Dan M D; Sorel, Claire; Tribouilloy, Christophe; Bernard, Yvette; Chirouze, Catherine; Hoen, Bruno; Leroy, Joel; Plesiat, Patrick; Naber, Christoph; Neuerburg, Carl; Mazaheri, Bahram; Naber, Christoph; Neuerburg, Carl; Athanasia, Sofia; Giannitsioti, Efthymia; Mylona, Elena; Paniara, Olga; Papanicolaou, Konstantinos; Pyros, John; Skoutelis, Athanasios; Sharma, Gautam; Francis, Johnson; Nair, Lathi; Thomas, Vinod; Venugopal, Krishnan; Hannan, Margaret; Hurley, John; Gilon, Dan; Israel, Sarah; Korem, Maya; Strahilevitz, Jacob; Rubinstein, Ethan; Strahilevitz, Jacob; Tripodi, Marie Françoise; Casillo, Roberta; Cuccurullo, Susanna; Dialetto, Giovanni; Durante-Mangoni, Emanuele; Irene, Mattucci; Ragone, Enrico; Utili, Riccardo; Cecchi, Enrico; De Rosa, Francesco; Forno, Davide; Imazio, Massimo; Trinchero, Rita; Tebini, Alessandro; Grossi, Paolo; Lattanzio, Mariangela; Toniolo, Antonio; Goglio, Antonio; Raglio, Annibale; Ravasio, Veronica; Rizzi, Marco; Suter, Fredy; Carosi, Giampiero; Magri, Silvia; Signorini, Liana; Baban, Tania; Kanafani, Zeina; Kanj, Souha S.; Sfeir, Jad; Yasmine, Mohamad; Abidin, Imran; Tamin, Syahidah Syed; Martínez, Eduardo Rivera; Nieto, Gabriel Israel Soto; van der Meer, Jan T M; Chambers, Stephen; Holland, David; Morris, Arthur; Raymond, Nigel; Read, Kerry; Murdoch, David R.; Dragulescu, Stefan; Ionac, Adina; Mornos, Cristian; Butkevich, O. M.; Chipigina, Natalia; Kirill, Ozerecky; Vadim, Kulichenko; Vinogradova, Tatiana; Edathodu, Jameela; Halim, Magid; Lum, Luh Nah; Tan, Ru San; Lejko-Zupanc, Tatjana; Logar, Mateja; Mueller-Premru, Manica; Commerford, Patrick; Commerford, Anita; Deetlefs, Eduan; Hansa, Cass; Ntsekhe, Mpiko; Almela, Manuel; Armero, Yolanda; Azqueta, Manuel; Castañeda, Ximena; Cervera, Carlos; Rio, Ana del; Falces, Carlos; Garcia-de-la-Maria, Cristina; Fita, Guillermina; Gatell, Jose M.; Marco, Francesc; Mestres, Carlos A.; Miró, José M.; Moreno, Asuncion; Ninot, Salvador; Paré, Carlos; Pericas, Joan; Ramirez, Jose; Rovira, Irene; Sitges, Marta; Anguera, Ignasi; Font, Bernat; Guma, Joan Raimon; Bermejo, Javier; Bouza, Emilio; Fernández, Miguel Angel Garcia; Gonzalez-Ramallo, Victor; Marín, Mercedes; Muñoz, Patricia; Pedromingo, Miguel; Roda, Jorge; Rodríguez-Créixems, Marta; Solis, Jorge; Almirante, Benito; Fernandez-Hidalgo, Nuria; Tornos, Pilar; de Alarcón, Arístides; Parra, Ricardo; Alestig, Eric; Johansson, Magnus; Olaison, Lars; Snygg-Martin, Ulrika; Pachirat, Orathai; Pachirat, Pimchitra; Pussadhamma, Burabha; Senthong, Vichai; Casey, Anna; Elliott, Tom; Lambert, Peter; Watkin, Richard; Eyton, Christina; Klein, John L.; Bradley, Suzanne; Kauffman, Carol; Bedimo, Roger; Chu, Vivian H.; Corey, G. Ralph; Crowley, Anna Lisa; Douglas, Pamela; Drew, Laura; Fowler, Vance G.; Holland, Thomas; Lalani, Tahaniyat; Mudrick, Daniel; Samad, Zaniab; Sexton, Daniel; Stryjewski, Martin; Wang, Andrew; Woods, Christopher W.; Lerakis, Stamatios; Cantey, Robert; Steed, Lisa; Wray, Dannah; Dickerman, Stuart A.; Bonilla, Hector; DiPersio, Joseph; Salstrom, Sara Jane; Baddley, John; Patel, Mukesh; Peterson, Gail; Stancoven, Amy; Afonso, Luis; Kulman, Theresa; Levine, Donald; Rybak, Michael; Cabell, Christopher H.; Baloch, Khaula; Chu, Vivian H.; Corey, G. Ralph; Dixon, Christy C.; Fowler, Vance G.; Harding, Tina; Jones-Richmond, Marian; Pappas, Paul; Park, Lawrence P.; Redick, Thomas; Stafford, Judy; Anstrom, Kevin; Athan, Eugene; Bayer, Arnold S.; Cabell, Christopher H.; Chu, Vivian H.; Hoen, Bruno; Karchmer, A. W.; Murdoch, David R.; Sexton, Daniel J.; Wang, Andrew; Bayer, Arnold S.; Cabell, Christopher H.; Chu, Vivian; Durack, David T.; Eykyn, Susannah; Hoen, Bruno; Moreillon, Phillipe; Olaison, Lars; Raoult, Didier; Rubinstein, Ethan.

In: PLoS One, Vol. 8, No. 5, e63181, 17.05.2013.

Research output: Contribution to journalArticle

Chambers, ST, Murdoch, D, Morris, A, Holland, D, Pappas, P, Almela, M, Fernández-Hidalgo, N, Almirante, B, Bouza, E, Forno, D, Rio, AD, Hannan, MM, Harkness, J, Kanafani, ZA, Lalani, T, Lang, S, Raymond, N, Read, K, Vinogradova, T, Woods, CW, Wray, D, Corey, GR, Chu, VH, Clara, L, Sanchez, M, Nacinovich, F, Oses, PF, Ronderos, R, Sucari, A, Thierer, J, Casabé, J, Cortes, C, Altclas, J, Silvia Kogan, S, Spelman, D, Athan, E, Harris, O, Kennedy, K, Tan, R, Gordon, D, Papanicolas, L, Eisen, D, Grigg, L, Street, A, Korman, T, Kotsanas, D, Dever, R, Jones, P, Konecny, P, Lawrence, R, Rees, D, Ryan, S, Feneley, MP, Harkness, J, Jones, P, Ryan, S, Jones, P, Ryan, S, Jones, P, Post, J, Reinbott, P, Ryan, S, Gattringer, R, Wiesbauer, F, Andrade, AR, de Brito, ACP, Guimarães, AC, Grinberg, M, Mansur, AJ, Siciliano, RF, Strabelli, TMV, Vieira, MLC, de Medeiros Tranchesi, RA, Paiva, MG, Fortes, CQ, de Oliveira Ramos, A, Ferraiuoli, G, Golebiovski, W, Lamas, C, Santos, M, Weksler, C, Karlowsky, JA, Keynan, Y, Morris, AM, Rubinstein, E, Jones, SB, Garcia, P, Cereceda, M, Fica, A, Mella, RM, Barsic, B, Bukovski, S, Krajinovic, V, Pangercic, A, Rudez, I, Vincelj, J, Freiberger, T, Pol, J, Zaloudikova, B, Ashour, Z, Kholy, AE, Mishaal, M, Rizk, H, Aissa, N, Alauzet, C, Alla, F, Campagnac, C, Doco-Lecompte, T, Selton-Suty, C, Casalta, JP, Fournier, PE, Habib, G, Raoult, D, Thuny, F, Delahaye, F, Delahaye, A, Vandenesch, F, Donal, E, Donnio, PY, Michelet, C, Revest, M, Tattevin, P, Violette, J, Chevalier, F, Jeu, A, Rusinaru, DMD, Sorel, C, Tribouilloy, C, Bernard, Y, Chirouze, C, Hoen, B, Leroy, J, Plesiat, P, Naber, C, Neuerburg, C, Mazaheri, B, Naber, C, Neuerburg, C, Athanasia, S, Giannitsioti, E, Mylona, E, Paniara, O, Papanicolaou, K, Pyros, J, Skoutelis, A, Sharma, G, Francis, J, Nair, L, Thomas, V, Venugopal, K, Hannan, M, Hurley, J, Gilon, D, Israel, S, Korem, M, Strahilevitz, J, Rubinstein, E, Strahilevitz, J, Tripodi, MF, Casillo, R, Cuccurullo, S, Dialetto, G, Durante-Mangoni, E, Irene, M, Ragone, E, Utili, R, Cecchi, E, De Rosa, F, Forno, D, Imazio, M, Trinchero, R, Tebini, A, Grossi, P, Lattanzio, M, Toniolo, A, Goglio, A, Raglio, A, Ravasio, V, Rizzi, M, Suter, F, Carosi, G, Magri, S, Signorini, L, Baban, T, Kanafani, Z, Kanj, SS, Sfeir, J, Yasmine, M, Abidin, I, Tamin, SS, Martínez, ER, Nieto, GIS, van der Meer, JTM, Chambers, S, Holland, D, Morris, A, Raymond, N, Read, K, Murdoch, DR, Dragulescu, S, Ionac, A, Mornos, C, Butkevich, OM, Chipigina, N, Kirill, O, Vadim, K, Vinogradova, T, Edathodu, J, Halim, M, Lum, LN, Tan, RS, Lejko-Zupanc, T, Logar, M, Mueller-Premru, M, Commerford, P, Commerford, A, Deetlefs, E, Hansa, C, Ntsekhe, M, Almela, M, Armero, Y, Azqueta, M, Castañeda, X, Cervera, C, Rio, AD, Falces, C, Garcia-de-la-Maria, C, Fita, G, Gatell, JM, Marco, F, Mestres, CA, Miró, JM, Moreno, A, Ninot, S, Paré, C, Pericas, J, Ramirez, J, Rovira, I, Sitges, M, Anguera, I, Font, B, Guma, JR, Bermejo, J, Bouza, E, Fernández, MAG, Gonzalez-Ramallo, V, Marín, M, Muñoz, P, Pedromingo, M, Roda, J, Rodríguez-Créixems, M, Solis, J, Almirante, B, Fernandez-Hidalgo, N, Tornos, P, de Alarcón, A, Parra, R, Alestig, E, Johansson, M, Olaison, L, Snygg-Martin, U, Pachirat, O, Pachirat, P, Pussadhamma, B, Senthong, V, Casey, A, Elliott, T, Lambert, P, Watkin, R, Eyton, C, Klein, JL, Bradley, S, Kauffman, C, Bedimo, R, Chu, VH, Corey, GR, Crowley, AL, Douglas, P, Drew, L, Fowler, VG, Holland, T, Lalani, T, Mudrick, D, Samad, Z, Sexton, D, Stryjewski, M, Wang, A, Woods, CW, Lerakis, S, Cantey, R, Steed, L, Wray, D, Dickerman, SA, Bonilla, H, DiPersio, J, Salstrom, SJ, Baddley, J, Patel, M, Peterson, G, Stancoven, A, Afonso, L, Kulman, T, Levine, D, Rybak, M, Cabell, CH, Baloch, K, Chu, VH, Corey, GR, Dixon, CC, Fowler, VG, Harding, T, Jones-Richmond, M, Pappas, P, Park, LP, Redick, T, Stafford, J, Anstrom, K, Athan, E, Bayer, AS, Cabell, CH, Chu, VH, Hoen, B, Karchmer, AW, Murdoch, DR, Sexton, DJ, Wang, A, Bayer, AS, Cabell, CH, Chu, V, Durack, DT, Eykyn, S, Hoen, B, Moreillon, P, Olaison, L, Raoult, D & Rubinstein, E 2013, 'HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort', PLoS One, vol. 8, no. 5, e63181. https://doi.org/10.1371/journal.pone.0063181
Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, Almela M et al. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort. PLoS One. 2013 May 17;8(5). e63181. https://doi.org/10.1371/journal.pone.0063181
Chambers, Stephen T. ; Murdoch, David ; Morris, Arthur ; Holland, David ; Pappas, Paul ; Almela, Manel ; Fernández-Hidalgo, Nuria ; Almirante, Benito ; Bouza, Emilio ; Forno, Davide ; Rio, Ana del ; Hannan, Margaret M. ; Harkness, John ; Kanafani, Zeina A. ; Lalani, Tahaniyat ; Lang, Selwyn ; Raymond, Nigel ; Read, Kerry ; Vinogradova, Tatiana ; Woods, Christopher W. ; Wray, Dannah ; Corey, G. Ralph ; Chu, Vivian H. ; Clara, Liliana ; Sanchez, Marisa ; Nacinovich, Francisco ; Oses, Pablo Fernandez ; Ronderos, Ricardo ; Sucari, Adriana ; Thierer, Jorge ; Casabé, José ; Cortes, Claudia ; Altclas, Javier ; Silvia Kogan, Sanatorio ; Spelman, Denis ; Athan, Eugene ; Harris, Owen ; Kennedy, Karina ; Tan, Ren ; Gordon, David ; Papanicolas, Lito ; Eisen, Damon ; Grigg, Leeanne ; Street, Alan ; Korman, Tony ; Kotsanas, Despina ; Dever, Robyn ; Jones, Phillip ; Konecny, Pam ; Lawrence, Richard ; Rees, David ; Ryan, Suzanne ; Feneley, Michael P. ; Harkness, John ; Jones, Phillip ; Ryan, Suzanne ; Jones, Phillip ; Ryan, Suzanne ; Jones, Phillip ; Post, Jeffrey ; Reinbott, Porl ; Ryan, Suzanne ; Gattringer, Rainer ; Wiesbauer, Franz ; Andrade, Adriana Ribas ; de Brito, Ana Cláudia Passos ; Guimarães, Armenio Costa ; Grinberg, Max ; Mansur, Alfredo José ; Siciliano, Rinaldo Focaccia ; Strabelli, Tania Mara Varejao ; Vieira, Marcelo Luiz Campos ; de Medeiros Tranchesi, Regina Aparecida ; Paiva, Marcelo Goulart ; Fortes, Claudio Querido ; de Oliveira Ramos, Auristela ; Ferraiuoli, Giovanna ; Golebiovski, Wilma ; Lamas, Cristiane ; Santos, Marisa ; Weksler, Clara ; Karlowsky, James A. ; Keynan, Yoav ; Morris, Andrew M. ; Rubinstein, Ethan ; Jones, Sandra Braun ; Garcia, Patricia ; Cereceda, M. ; Fica, Alberto ; Mella, Rodrigo Montagna ; Barsic, Bruno ; Bukovski, Suzana ; Krajinovic, Vladimir ; Pangercic, Ana ; Rudez, Igor ; Vincelj, Josip ; Freiberger, Tomas ; Pol, Jiri ; Zaloudikova, Barbora ; Ashour, Zainab ; Kholy, Amani El ; Mishaal, Marwa ; Rizk, Hussien ; Aissa, Neijla ; Alauzet, Corentine ; Alla, Francois ; Campagnac, Catherine ; Doco-Lecompte, Thanh ; Selton-Suty, Christine ; Casalta, Jean Paul ; Fournier, Pierre Edouard ; Habib, Gilbert ; Raoult, Didier ; Thuny, Franck ; Delahaye, Francois ; Delahaye, Armelle ; Vandenesch, Francois ; Donal, Erwan ; Donnio, Pierre Yves ; Michelet, Christian ; Revest, Matthieu ; Tattevin, Pierre ; Violette, Jérémie ; Chevalier, Florent ; Jeu, Antoine ; Rusinaru, Dan M D ; Sorel, Claire ; Tribouilloy, Christophe ; Bernard, Yvette ; Chirouze, Catherine ; Hoen, Bruno ; Leroy, Joel ; Plesiat, Patrick ; Naber, Christoph ; Neuerburg, Carl ; Mazaheri, Bahram ; Naber, Christoph ; Neuerburg, Carl ; Athanasia, Sofia ; Giannitsioti, Efthymia ; Mylona, Elena ; Paniara, Olga ; Papanicolaou, Konstantinos ; Pyros, John ; Skoutelis, Athanasios ; Sharma, Gautam ; Francis, Johnson ; Nair, Lathi ; Thomas, Vinod ; Venugopal, Krishnan ; Hannan, Margaret ; Hurley, John ; Gilon, Dan ; Israel, Sarah ; Korem, Maya ; Strahilevitz, Jacob ; Rubinstein, Ethan ; Strahilevitz, Jacob ; Tripodi, Marie Françoise ; Casillo, Roberta ; Cuccurullo, Susanna ; Dialetto, Giovanni ; Durante-Mangoni, Emanuele ; Irene, Mattucci ; Ragone, Enrico ; Utili, Riccardo ; Cecchi, Enrico ; De Rosa, Francesco ; Forno, Davide ; Imazio, Massimo ; Trinchero, Rita ; Tebini, Alessandro ; Grossi, Paolo ; Lattanzio, Mariangela ; Toniolo, Antonio ; Goglio, Antonio ; Raglio, Annibale ; Ravasio, Veronica ; Rizzi, Marco ; Suter, Fredy ; Carosi, Giampiero ; Magri, Silvia ; Signorini, Liana ; Baban, Tania ; Kanafani, Zeina ; Kanj, Souha S. ; Sfeir, Jad ; Yasmine, Mohamad ; Abidin, Imran ; Tamin, Syahidah Syed ; Martínez, Eduardo Rivera ; Nieto, Gabriel Israel Soto ; van der Meer, Jan T M ; Chambers, Stephen ; Holland, David ; Morris, Arthur ; Raymond, Nigel ; Read, Kerry ; Murdoch, David R. ; Dragulescu, Stefan ; Ionac, Adina ; Mornos, Cristian ; Butkevich, O. M. ; Chipigina, Natalia ; Kirill, Ozerecky ; Vadim, Kulichenko ; Vinogradova, Tatiana ; Edathodu, Jameela ; Halim, Magid ; Lum, Luh Nah ; Tan, Ru San ; Lejko-Zupanc, Tatjana ; Logar, Mateja ; Mueller-Premru, Manica ; Commerford, Patrick ; Commerford, Anita ; Deetlefs, Eduan ; Hansa, Cass ; Ntsekhe, Mpiko ; Almela, Manuel ; Armero, Yolanda ; Azqueta, Manuel ; Castañeda, Ximena ; Cervera, Carlos ; Rio, Ana del ; Falces, Carlos ; Garcia-de-la-Maria, Cristina ; Fita, Guillermina ; Gatell, Jose M. ; Marco, Francesc ; Mestres, Carlos A. ; Miró, José M. ; Moreno, Asuncion ; Ninot, Salvador ; Paré, Carlos ; Pericas, Joan ; Ramirez, Jose ; Rovira, Irene ; Sitges, Marta ; Anguera, Ignasi ; Font, Bernat ; Guma, Joan Raimon ; Bermejo, Javier ; Bouza, Emilio ; Fernández, Miguel Angel Garcia ; Gonzalez-Ramallo, Victor ; Marín, Mercedes ; Muñoz, Patricia ; Pedromingo, Miguel ; Roda, Jorge ; Rodríguez-Créixems, Marta ; Solis, Jorge ; Almirante, Benito ; Fernandez-Hidalgo, Nuria ; Tornos, Pilar ; de Alarcón, Arístides ; Parra, Ricardo ; Alestig, Eric ; Johansson, Magnus ; Olaison, Lars ; Snygg-Martin, Ulrika ; Pachirat, Orathai ; Pachirat, Pimchitra ; Pussadhamma, Burabha ; Senthong, Vichai ; Casey, Anna ; Elliott, Tom ; Lambert, Peter ; Watkin, Richard ; Eyton, Christina ; Klein, John L. ; Bradley, Suzanne ; Kauffman, Carol ; Bedimo, Roger ; Chu, Vivian H. ; Corey, G. Ralph ; Crowley, Anna Lisa ; Douglas, Pamela ; Drew, Laura ; Fowler, Vance G. ; Holland, Thomas ; Lalani, Tahaniyat ; Mudrick, Daniel ; Samad, Zaniab ; Sexton, Daniel ; Stryjewski, Martin ; Wang, Andrew ; Woods, Christopher W. ; Lerakis, Stamatios ; Cantey, Robert ; Steed, Lisa ; Wray, Dannah ; Dickerman, Stuart A. ; Bonilla, Hector ; DiPersio, Joseph ; Salstrom, Sara Jane ; Baddley, John ; Patel, Mukesh ; Peterson, Gail ; Stancoven, Amy ; Afonso, Luis ; Kulman, Theresa ; Levine, Donald ; Rybak, Michael ; Cabell, Christopher H. ; Baloch, Khaula ; Chu, Vivian H. ; Corey, G. Ralph ; Dixon, Christy C. ; Fowler, Vance G. ; Harding, Tina ; Jones-Richmond, Marian ; Pappas, Paul ; Park, Lawrence P. ; Redick, Thomas ; Stafford, Judy ; Anstrom, Kevin ; Athan, Eugene ; Bayer, Arnold S. ; Cabell, Christopher H. ; Chu, Vivian H. ; Hoen, Bruno ; Karchmer, A. W. ; Murdoch, David R. ; Sexton, Daniel J. ; Wang, Andrew ; Bayer, Arnold S. ; Cabell, Christopher H. ; Chu, Vivian ; Durack, David T. ; Eykyn, Susannah ; Hoen, Bruno ; Moreillon, Phillipe ; Olaison, Lars ; Raoult, Didier ; Rubinstein, Ethan. / HACEK Infective Endocarditis : Characteristics and Outcomes from a Large, Multi-National Cohort. In: PLoS One. 2013 ; Vol. 8, No. 5.
@article{98203afb0e184fd896f2a00821f81ec9,
title = "HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort",
abstract = "The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4{\%}) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32{\%} vs. 20{\%}; p<0.008) and stroke (25{\%} vs. 17{\%} p = 0.05) but a lower prevalence of congestive heart failure (15{\%} vs. 30{\%}; p = 0.004), death in-hospital (4{\%} vs. 18{\%}; p = 0.001) or after 1 year follow-up (6{\%} vs. 20{\%}; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4{\%}) significantly better than for non-HE (18{\%}; p<0.001). Prosthetic valve endocarditis was more common in HE (35{\%}) than non-HE (24{\%}). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.",
author = "Chambers, {Stephen T.} and David Murdoch and Arthur Morris and David Holland and Paul Pappas and Manel Almela and Nuria Fern{\'a}ndez-Hidalgo and Benito Almirante and Emilio Bouza and Davide Forno and Rio, {Ana del} and Hannan, {Margaret M.} and John Harkness and Kanafani, {Zeina A.} and Tahaniyat Lalani and Selwyn Lang and Nigel Raymond and Kerry Read and Tatiana Vinogradova and Woods, {Christopher W.} and Dannah Wray and Corey, {G. Ralph} and Chu, {Vivian H.} and Liliana Clara and Marisa Sanchez and Francisco Nacinovich and Oses, {Pablo Fernandez} and Ricardo Ronderos and Adriana Sucari and Jorge Thierer and Jos{\'e} Casab{\'e} and Claudia Cortes and Javier Altclas and {Silvia Kogan}, Sanatorio and Denis Spelman and Eugene Athan and Owen Harris and Karina Kennedy and Ren Tan and David Gordon and Lito Papanicolas and Damon Eisen and Leeanne Grigg and Alan Street and Tony Korman and Despina Kotsanas and Robyn Dever and Phillip Jones and Pam Konecny and Richard Lawrence and David Rees and Suzanne Ryan and Feneley, {Michael P.} and John Harkness and Phillip Jones and Suzanne Ryan and Phillip Jones and Suzanne Ryan and Phillip Jones and Jeffrey Post and Porl Reinbott and Suzanne Ryan and Rainer Gattringer and Franz Wiesbauer and Andrade, {Adriana Ribas} and {de Brito}, {Ana Cl{\'a}udia Passos} and Guimar{\~a}es, {Armenio Costa} and Max Grinberg and Mansur, {Alfredo Jos{\'e}} and Siciliano, {Rinaldo Focaccia} and Strabelli, {Tania Mara Varejao} and Vieira, {Marcelo Luiz Campos} and {de Medeiros Tranchesi}, {Regina Aparecida} and Paiva, {Marcelo Goulart} and Fortes, {Claudio Querido} and {de Oliveira Ramos}, Auristela and Giovanna Ferraiuoli and Wilma Golebiovski and Cristiane Lamas and Marisa Santos and Clara Weksler and Karlowsky, {James A.} and Yoav Keynan and Morris, {Andrew M.} and Ethan Rubinstein and Jones, {Sandra Braun} and Patricia Garcia and M. Cereceda and Alberto Fica and Mella, {Rodrigo Montagna} and Bruno Barsic and Suzana Bukovski and Vladimir Krajinovic and Ana Pangercic and Igor Rudez and Josip Vincelj and Tomas Freiberger and Jiri Pol and Barbora Zaloudikova and Zainab Ashour and Kholy, {Amani El} and Marwa Mishaal and Hussien Rizk and Neijla Aissa and Corentine Alauzet and Francois Alla and Catherine Campagnac and Thanh Doco-Lecompte and Christine Selton-Suty and Casalta, {Jean Paul} and Fournier, {Pierre Edouard} and Gilbert Habib and Didier Raoult and Franck Thuny and Francois Delahaye and Armelle Delahaye and Francois Vandenesch and Erwan Donal and Donnio, {Pierre Yves} and Christian Michelet and Matthieu Revest and Pierre Tattevin and J{\'e}r{\'e}mie Violette and Florent Chevalier and Antoine Jeu and Rusinaru, {Dan M D} and Claire Sorel and Christophe Tribouilloy and Yvette Bernard and Catherine Chirouze and Bruno Hoen and Joel Leroy and Patrick Plesiat and Christoph Naber and Carl Neuerburg and Bahram Mazaheri and Christoph Naber and Carl Neuerburg and Sofia Athanasia and Efthymia Giannitsioti and Elena Mylona and Olga Paniara and Konstantinos Papanicolaou and John Pyros and Athanasios Skoutelis and Gautam Sharma and Johnson Francis and Lathi Nair and Vinod Thomas and Krishnan Venugopal and Margaret Hannan and John Hurley and Dan Gilon and Sarah Israel and Maya Korem and Jacob Strahilevitz and Ethan Rubinstein and Jacob Strahilevitz and Tripodi, {Marie Fran{\cc}oise} and Roberta Casillo and Susanna Cuccurullo and Giovanni Dialetto and Emanuele Durante-Mangoni and Mattucci Irene and Enrico Ragone and Riccardo Utili and Enrico Cecchi and {De Rosa}, Francesco and Davide Forno and Massimo Imazio and Rita Trinchero and Alessandro Tebini and Paolo Grossi and Mariangela Lattanzio and Antonio Toniolo and Antonio Goglio and Annibale Raglio and Veronica Ravasio and Marco Rizzi and Fredy Suter and Giampiero Carosi and Silvia Magri and Liana Signorini and Tania Baban and Zeina Kanafani and Kanj, {Souha S.} and Jad Sfeir and Mohamad Yasmine and Imran Abidin and Tamin, {Syahidah Syed} and Mart{\'i}nez, {Eduardo Rivera} and Nieto, {Gabriel Israel Soto} and {van der Meer}, {Jan T M} and Stephen Chambers and David Holland and Arthur Morris and Nigel Raymond and Kerry Read and Murdoch, {David R.} and Stefan Dragulescu and Adina Ionac and Cristian Mornos and Butkevich, {O. M.} and Natalia Chipigina and Ozerecky Kirill and Kulichenko Vadim and Tatiana Vinogradova and Jameela Edathodu and Magid Halim and Lum, {Luh Nah} and Tan, {Ru San} and Tatjana Lejko-Zupanc and Mateja Logar and Manica Mueller-Premru and Patrick Commerford and Anita Commerford and Eduan Deetlefs and Cass Hansa and Mpiko Ntsekhe and Manuel Almela and Yolanda Armero and Manuel Azqueta and Ximena Casta{\~n}eda and Carlos Cervera and Rio, {Ana del} and Carlos Falces and Cristina Garcia-de-la-Maria and Guillermina Fita and Gatell, {Jose M.} and Francesc Marco and Mestres, {Carlos A.} and Mir{\'o}, {Jos{\'e} M.} and Asuncion Moreno and Salvador Ninot and Carlos Par{\'e} and Joan Pericas and Jose Ramirez and Irene Rovira and Marta Sitges and Ignasi Anguera and Bernat Font and Guma, {Joan Raimon} and Javier Bermejo and Emilio Bouza and Fern{\'a}ndez, {Miguel Angel Garcia} and Victor Gonzalez-Ramallo and Mercedes Mar{\'i}n and Patricia Mu{\~n}oz and Miguel Pedromingo and Jorge Roda and Marta Rodr{\'i}guez-Cr{\'e}ixems and Jorge Solis and Benito Almirante and Nuria Fernandez-Hidalgo and Pilar Tornos and {de Alarc{\'o}n}, Ar{\'i}stides and Ricardo Parra and Eric Alestig and Magnus Johansson and Lars Olaison and Ulrika Snygg-Martin and Orathai Pachirat and Pimchitra Pachirat and Burabha Pussadhamma and Vichai Senthong and Anna Casey and Tom Elliott and Peter Lambert and Richard Watkin and Christina Eyton and Klein, {John L.} and Suzanne Bradley and Carol Kauffman and Roger Bedimo and Chu, {Vivian H.} and Corey, {G. Ralph} and Crowley, {Anna Lisa} and Pamela Douglas and Laura Drew and Fowler, {Vance G.} and Thomas Holland and Tahaniyat Lalani and Daniel Mudrick and Zaniab Samad and Daniel Sexton and Martin Stryjewski and Andrew Wang and Woods, {Christopher W.} and Stamatios Lerakis and Robert Cantey and Lisa Steed and Dannah Wray and Dickerman, {Stuart A.} and Hector Bonilla and Joseph DiPersio and Salstrom, {Sara Jane} and John Baddley and Mukesh Patel and Gail Peterson and Amy Stancoven and Luis Afonso and Theresa Kulman and Donald Levine and Michael Rybak and Cabell, {Christopher H.} and Khaula Baloch and Chu, {Vivian H.} and Corey, {G. Ralph} and Dixon, {Christy C.} and Fowler, {Vance G.} and Tina Harding and Marian Jones-Richmond and Paul Pappas and Park, {Lawrence P.} and Thomas Redick and Judy Stafford and Kevin Anstrom and Eugene Athan and Bayer, {Arnold S.} and Cabell, {Christopher H.} and Chu, {Vivian H.} and Bruno Hoen and Karchmer, {A. W.} and Murdoch, {David R.} and Sexton, {Daniel J.} and Andrew Wang and Bayer, {Arnold S.} and Cabell, {Christopher H.} and Vivian Chu and Durack, {David T.} and Susannah Eykyn and Bruno Hoen and Phillipe Moreillon and Lars Olaison and Didier Raoult and Ethan Rubinstein",
year = "2013",
month = "5",
day = "17",
doi = "10.1371/journal.pone.0063181",
language = "English (US)",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - HACEK Infective Endocarditis

T2 - Characteristics and Outcomes from a Large, Multi-National Cohort

AU - Chambers, Stephen T.

AU - Murdoch, David

AU - Morris, Arthur

AU - Holland, David

AU - Pappas, Paul

AU - Almela, Manel

AU - Fernández-Hidalgo, Nuria

AU - Almirante, Benito

AU - Bouza, Emilio

AU - Forno, Davide

AU - Rio, Ana del

AU - Hannan, Margaret M.

AU - Harkness, John

AU - Kanafani, Zeina A.

AU - Lalani, Tahaniyat

AU - Lang, Selwyn

AU - Raymond, Nigel

AU - Read, Kerry

AU - Vinogradova, Tatiana

AU - Woods, Christopher W.

AU - Wray, Dannah

AU - Corey, G. Ralph

AU - Chu, Vivian H.

AU - Clara, Liliana

AU - Sanchez, Marisa

AU - Nacinovich, Francisco

AU - Oses, Pablo Fernandez

AU - Ronderos, Ricardo

AU - Sucari, Adriana

AU - Thierer, Jorge

AU - Casabé, José

AU - Cortes, Claudia

AU - Altclas, Javier

AU - Silvia Kogan, Sanatorio

AU - Spelman, Denis

AU - Athan, Eugene

AU - Harris, Owen

AU - Kennedy, Karina

AU - Tan, Ren

AU - Gordon, David

AU - Papanicolas, Lito

AU - Eisen, Damon

AU - Grigg, Leeanne

AU - Street, Alan

AU - Korman, Tony

AU - Kotsanas, Despina

AU - Dever, Robyn

AU - Jones, Phillip

AU - Konecny, Pam

AU - Lawrence, Richard

AU - Rees, David

AU - Ryan, Suzanne

AU - Feneley, Michael P.

AU - Harkness, John

AU - Jones, Phillip

AU - Ryan, Suzanne

AU - Jones, Phillip

AU - Ryan, Suzanne

AU - Jones, Phillip

AU - Post, Jeffrey

AU - Reinbott, Porl

AU - Ryan, Suzanne

AU - Gattringer, Rainer

AU - Wiesbauer, Franz

AU - Andrade, Adriana Ribas

AU - de Brito, Ana Cláudia Passos

AU - Guimarães, Armenio Costa

AU - Grinberg, Max

AU - Mansur, Alfredo José

AU - Siciliano, Rinaldo Focaccia

AU - Strabelli, Tania Mara Varejao

AU - Vieira, Marcelo Luiz Campos

AU - de Medeiros Tranchesi, Regina Aparecida

AU - Paiva, Marcelo Goulart

AU - Fortes, Claudio Querido

AU - de Oliveira Ramos, Auristela

AU - Ferraiuoli, Giovanna

AU - Golebiovski, Wilma

AU - Lamas, Cristiane

AU - Santos, Marisa

AU - Weksler, Clara

AU - Karlowsky, James A.

AU - Keynan, Yoav

AU - Morris, Andrew M.

AU - Rubinstein, Ethan

AU - Jones, Sandra Braun

AU - Garcia, Patricia

AU - Cereceda, M.

AU - Fica, Alberto

AU - Mella, Rodrigo Montagna

AU - Barsic, Bruno

AU - Bukovski, Suzana

AU - Krajinovic, Vladimir

AU - Pangercic, Ana

AU - Rudez, Igor

AU - Vincelj, Josip

AU - Freiberger, Tomas

AU - Pol, Jiri

AU - Zaloudikova, Barbora

AU - Ashour, Zainab

AU - Kholy, Amani El

AU - Mishaal, Marwa

AU - Rizk, Hussien

AU - Aissa, Neijla

AU - Alauzet, Corentine

AU - Alla, Francois

AU - Campagnac, Catherine

AU - Doco-Lecompte, Thanh

AU - Selton-Suty, Christine

AU - Casalta, Jean Paul

AU - Fournier, Pierre Edouard

AU - Habib, Gilbert

AU - Raoult, Didier

AU - Thuny, Franck

AU - Delahaye, Francois

AU - Delahaye, Armelle

AU - Vandenesch, Francois

AU - Donal, Erwan

AU - Donnio, Pierre Yves

AU - Michelet, Christian

AU - Revest, Matthieu

AU - Tattevin, Pierre

AU - Violette, Jérémie

AU - Chevalier, Florent

AU - Jeu, Antoine

AU - Rusinaru, Dan M D

AU - Sorel, Claire

AU - Tribouilloy, Christophe

AU - Bernard, Yvette

AU - Chirouze, Catherine

AU - Hoen, Bruno

AU - Leroy, Joel

AU - Plesiat, Patrick

AU - Naber, Christoph

AU - Neuerburg, Carl

AU - Mazaheri, Bahram

AU - Naber, Christoph

AU - Neuerburg, Carl

AU - Athanasia, Sofia

AU - Giannitsioti, Efthymia

AU - Mylona, Elena

AU - Paniara, Olga

AU - Papanicolaou, Konstantinos

AU - Pyros, John

AU - Skoutelis, Athanasios

AU - Sharma, Gautam

AU - Francis, Johnson

AU - Nair, Lathi

AU - Thomas, Vinod

AU - Venugopal, Krishnan

AU - Hannan, Margaret

AU - Hurley, John

AU - Gilon, Dan

AU - Israel, Sarah

AU - Korem, Maya

AU - Strahilevitz, Jacob

AU - Rubinstein, Ethan

AU - Strahilevitz, Jacob

AU - Tripodi, Marie Françoise

AU - Casillo, Roberta

AU - Cuccurullo, Susanna

AU - Dialetto, Giovanni

AU - Durante-Mangoni, Emanuele

AU - Irene, Mattucci

AU - Ragone, Enrico

AU - Utili, Riccardo

AU - Cecchi, Enrico

AU - De Rosa, Francesco

AU - Forno, Davide

AU - Imazio, Massimo

AU - Trinchero, Rita

AU - Tebini, Alessandro

AU - Grossi, Paolo

AU - Lattanzio, Mariangela

AU - Toniolo, Antonio

AU - Goglio, Antonio

AU - Raglio, Annibale

AU - Ravasio, Veronica

AU - Rizzi, Marco

AU - Suter, Fredy

AU - Carosi, Giampiero

AU - Magri, Silvia

AU - Signorini, Liana

AU - Baban, Tania

AU - Kanafani, Zeina

AU - Kanj, Souha S.

AU - Sfeir, Jad

AU - Yasmine, Mohamad

AU - Abidin, Imran

AU - Tamin, Syahidah Syed

AU - Martínez, Eduardo Rivera

AU - Nieto, Gabriel Israel Soto

AU - van der Meer, Jan T M

AU - Chambers, Stephen

AU - Holland, David

AU - Morris, Arthur

AU - Raymond, Nigel

AU - Read, Kerry

AU - Murdoch, David R.

AU - Dragulescu, Stefan

AU - Ionac, Adina

AU - Mornos, Cristian

AU - Butkevich, O. M.

AU - Chipigina, Natalia

AU - Kirill, Ozerecky

AU - Vadim, Kulichenko

AU - Vinogradova, Tatiana

AU - Edathodu, Jameela

AU - Halim, Magid

AU - Lum, Luh Nah

AU - Tan, Ru San

AU - Lejko-Zupanc, Tatjana

AU - Logar, Mateja

AU - Mueller-Premru, Manica

AU - Commerford, Patrick

AU - Commerford, Anita

AU - Deetlefs, Eduan

AU - Hansa, Cass

AU - Ntsekhe, Mpiko

AU - Almela, Manuel

AU - Armero, Yolanda

AU - Azqueta, Manuel

AU - Castañeda, Ximena

AU - Cervera, Carlos

AU - Rio, Ana del

AU - Falces, Carlos

AU - Garcia-de-la-Maria, Cristina

AU - Fita, Guillermina

AU - Gatell, Jose M.

AU - Marco, Francesc

AU - Mestres, Carlos A.

AU - Miró, José M.

AU - Moreno, Asuncion

AU - Ninot, Salvador

AU - Paré, Carlos

AU - Pericas, Joan

AU - Ramirez, Jose

AU - Rovira, Irene

AU - Sitges, Marta

AU - Anguera, Ignasi

AU - Font, Bernat

AU - Guma, Joan Raimon

AU - Bermejo, Javier

AU - Bouza, Emilio

AU - Fernández, Miguel Angel Garcia

AU - Gonzalez-Ramallo, Victor

AU - Marín, Mercedes

AU - Muñoz, Patricia

AU - Pedromingo, Miguel

AU - Roda, Jorge

AU - Rodríguez-Créixems, Marta

AU - Solis, Jorge

AU - Almirante, Benito

AU - Fernandez-Hidalgo, Nuria

AU - Tornos, Pilar

AU - de Alarcón, Arístides

AU - Parra, Ricardo

AU - Alestig, Eric

AU - Johansson, Magnus

AU - Olaison, Lars

AU - Snygg-Martin, Ulrika

AU - Pachirat, Orathai

AU - Pachirat, Pimchitra

AU - Pussadhamma, Burabha

AU - Senthong, Vichai

AU - Casey, Anna

AU - Elliott, Tom

AU - Lambert, Peter

AU - Watkin, Richard

AU - Eyton, Christina

AU - Klein, John L.

AU - Bradley, Suzanne

AU - Kauffman, Carol

AU - Bedimo, Roger

AU - Chu, Vivian H.

AU - Corey, G. Ralph

AU - Crowley, Anna Lisa

AU - Douglas, Pamela

AU - Drew, Laura

AU - Fowler, Vance G.

AU - Holland, Thomas

AU - Lalani, Tahaniyat

AU - Mudrick, Daniel

AU - Samad, Zaniab

AU - Sexton, Daniel

AU - Stryjewski, Martin

AU - Wang, Andrew

AU - Woods, Christopher W.

AU - Lerakis, Stamatios

AU - Cantey, Robert

AU - Steed, Lisa

AU - Wray, Dannah

AU - Dickerman, Stuart A.

AU - Bonilla, Hector

AU - DiPersio, Joseph

AU - Salstrom, Sara Jane

AU - Baddley, John

AU - Patel, Mukesh

AU - Peterson, Gail

AU - Stancoven, Amy

AU - Afonso, Luis

AU - Kulman, Theresa

AU - Levine, Donald

AU - Rybak, Michael

AU - Cabell, Christopher H.

AU - Baloch, Khaula

AU - Chu, Vivian H.

AU - Corey, G. Ralph

AU - Dixon, Christy C.

AU - Fowler, Vance G.

AU - Harding, Tina

AU - Jones-Richmond, Marian

AU - Pappas, Paul

AU - Park, Lawrence P.

AU - Redick, Thomas

AU - Stafford, Judy

AU - Anstrom, Kevin

AU - Athan, Eugene

AU - Bayer, Arnold S.

AU - Cabell, Christopher H.

AU - Chu, Vivian H.

AU - Hoen, Bruno

AU - Karchmer, A. W.

AU - Murdoch, David R.

AU - Sexton, Daniel J.

AU - Wang, Andrew

AU - Bayer, Arnold S.

AU - Cabell, Christopher H.

AU - Chu, Vivian

AU - Durack, David T.

AU - Eykyn, Susannah

AU - Hoen, Bruno

AU - Moreillon, Phillipe

AU - Olaison, Lars

AU - Raoult, Didier

AU - Rubinstein, Ethan

PY - 2013/5/17

Y1 - 2013/5/17

N2 - The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.

AB - The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.

UR - http://www.scopus.com/inward/record.url?scp=84877859498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877859498&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0063181

DO - 10.1371/journal.pone.0063181

M3 - Article

C2 - 23690995

AN - SCOPUS:84877859498

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e63181

ER -