Haematogones in the peripheral blood of adults: A four-colour flow cytometry study of 102 patients

Steven H. Kroft, Sheryl L. Asplund, Robert W. McKenna, Nitin J. Karandikar

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 × 109/l (median 0.0054 × 109/l, mean 0.012 × 109/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalBritish Journal of Haematology
Volume126
Issue number2
DOIs
StatePublished - Jul 2004

Keywords

  • B-cell precursors
  • CD10
  • Flow cytometry
  • Haematogones

ASJC Scopus subject areas

  • Hematology

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