Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function

A. De Hoyos, P. P. Liu, D. C. Benard, T. D. Bradley

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

1. Continuous positive airway pressure increases intrathoracic pressure, thereby decreasing left ventricular preload and afterload. We hypothesized that there would be a dose-related alteration in cardiac and stroke volume indices in response to continuous positive airway pressure in normal subjects and patients with congestive heart failure and that the direction of response among those with heart failure would be related to left ventricular preload. 2. Cardiac and stroke volume indices were measured at baseline and after 10 min of continuous positive airway pressure at both 5 and 10 cmH2O (0.5 and 0.99 kPa respectively) in 16 patients with heart failure and five control subjects with normal cardiac function. Among the eight patients with heart failure and elevated pulmonary capillary wedge pressure (≥12 mmHg) (≥1.6 kPa), cardiac index increased from 2.47 ± 0.34 at baseline to 2.91 ± 0.32 to 3.12 ± 0.40 l min-1 m-2 (P < 0.025) while on 5 and 10 cm H2O of continuous positive airway pressure respectively. In the same patients stroke volume index increased from 27.8 ± 3.9 to 33.9 ± 4.2 to 36.8 ± 5.5 ml/m2 (P < 0.05). In contrast, in both the control subjects and patients with heart failure and normal pulmonary capillary wedge pressure (<12 mmHg) there was a dose-related decrease in cardiac and stroke volume indices while on continuous positive airway pressure. 3. Continuous positive airway pressure causes dose-related increases in cardiac and stroke volume indices among patients with chronic heart failure and elevated left ventricular filling pressure. However, it induces dose-related reductions in cardiac and stroke volume indices among normal subjects as well as patients with heart failure and normal left ventricular filling pressures.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalClinical Science
Volume88
Issue number2
StatePublished - Feb 3 1995

Fingerprint

Continuous Positive Airway Pressure
Left Ventricular Function
Cardiac Volume
Stroke Volume
Heart Failure
Hemodynamics
Pulmonary Wedge Pressure
Ventricular Pressure
Pressure

Keywords

  • Congestive heart failure
  • Continuous positive airway pressure
  • Haemodynamics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function. / De Hoyos, A.; Liu, P. P.; Benard, D. C.; Bradley, T. D.

In: Clinical Science, Vol. 88, No. 2, 03.02.1995, p. 173-178.

Research output: Contribution to journalArticle

@article{6745ceb2760c4cca99c75635b76c0958,
title = "Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function",
abstract = "1. Continuous positive airway pressure increases intrathoracic pressure, thereby decreasing left ventricular preload and afterload. We hypothesized that there would be a dose-related alteration in cardiac and stroke volume indices in response to continuous positive airway pressure in normal subjects and patients with congestive heart failure and that the direction of response among those with heart failure would be related to left ventricular preload. 2. Cardiac and stroke volume indices were measured at baseline and after 10 min of continuous positive airway pressure at both 5 and 10 cmH2O (0.5 and 0.99 kPa respectively) in 16 patients with heart failure and five control subjects with normal cardiac function. Among the eight patients with heart failure and elevated pulmonary capillary wedge pressure (≥12 mmHg) (≥1.6 kPa), cardiac index increased from 2.47 ± 0.34 at baseline to 2.91 ± 0.32 to 3.12 ± 0.40 l min-1 m-2 (P < 0.025) while on 5 and 10 cm H2O of continuous positive airway pressure respectively. In the same patients stroke volume index increased from 27.8 ± 3.9 to 33.9 ± 4.2 to 36.8 ± 5.5 ml/m2 (P < 0.05). In contrast, in both the control subjects and patients with heart failure and normal pulmonary capillary wedge pressure (<12 mmHg) there was a dose-related decrease in cardiac and stroke volume indices while on continuous positive airway pressure. 3. Continuous positive airway pressure causes dose-related increases in cardiac and stroke volume indices among patients with chronic heart failure and elevated left ventricular filling pressure. However, it induces dose-related reductions in cardiac and stroke volume indices among normal subjects as well as patients with heart failure and normal left ventricular filling pressures.",
keywords = "Congestive heart failure, Continuous positive airway pressure, Haemodynamics",
author = "{De Hoyos}, A. and Liu, {P. P.} and Benard, {D. C.} and Bradley, {T. D.}",
year = "1995",
month = "2",
day = "3",
language = "English (US)",
volume = "88",
pages = "173--178",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "2",

}

TY - JOUR

T1 - Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function

AU - De Hoyos, A.

AU - Liu, P. P.

AU - Benard, D. C.

AU - Bradley, T. D.

PY - 1995/2/3

Y1 - 1995/2/3

N2 - 1. Continuous positive airway pressure increases intrathoracic pressure, thereby decreasing left ventricular preload and afterload. We hypothesized that there would be a dose-related alteration in cardiac and stroke volume indices in response to continuous positive airway pressure in normal subjects and patients with congestive heart failure and that the direction of response among those with heart failure would be related to left ventricular preload. 2. Cardiac and stroke volume indices were measured at baseline and after 10 min of continuous positive airway pressure at both 5 and 10 cmH2O (0.5 and 0.99 kPa respectively) in 16 patients with heart failure and five control subjects with normal cardiac function. Among the eight patients with heart failure and elevated pulmonary capillary wedge pressure (≥12 mmHg) (≥1.6 kPa), cardiac index increased from 2.47 ± 0.34 at baseline to 2.91 ± 0.32 to 3.12 ± 0.40 l min-1 m-2 (P < 0.025) while on 5 and 10 cm H2O of continuous positive airway pressure respectively. In the same patients stroke volume index increased from 27.8 ± 3.9 to 33.9 ± 4.2 to 36.8 ± 5.5 ml/m2 (P < 0.05). In contrast, in both the control subjects and patients with heart failure and normal pulmonary capillary wedge pressure (<12 mmHg) there was a dose-related decrease in cardiac and stroke volume indices while on continuous positive airway pressure. 3. Continuous positive airway pressure causes dose-related increases in cardiac and stroke volume indices among patients with chronic heart failure and elevated left ventricular filling pressure. However, it induces dose-related reductions in cardiac and stroke volume indices among normal subjects as well as patients with heart failure and normal left ventricular filling pressures.

AB - 1. Continuous positive airway pressure increases intrathoracic pressure, thereby decreasing left ventricular preload and afterload. We hypothesized that there would be a dose-related alteration in cardiac and stroke volume indices in response to continuous positive airway pressure in normal subjects and patients with congestive heart failure and that the direction of response among those with heart failure would be related to left ventricular preload. 2. Cardiac and stroke volume indices were measured at baseline and after 10 min of continuous positive airway pressure at both 5 and 10 cmH2O (0.5 and 0.99 kPa respectively) in 16 patients with heart failure and five control subjects with normal cardiac function. Among the eight patients with heart failure and elevated pulmonary capillary wedge pressure (≥12 mmHg) (≥1.6 kPa), cardiac index increased from 2.47 ± 0.34 at baseline to 2.91 ± 0.32 to 3.12 ± 0.40 l min-1 m-2 (P < 0.025) while on 5 and 10 cm H2O of continuous positive airway pressure respectively. In the same patients stroke volume index increased from 27.8 ± 3.9 to 33.9 ± 4.2 to 36.8 ± 5.5 ml/m2 (P < 0.05). In contrast, in both the control subjects and patients with heart failure and normal pulmonary capillary wedge pressure (<12 mmHg) there was a dose-related decrease in cardiac and stroke volume indices while on continuous positive airway pressure. 3. Continuous positive airway pressure causes dose-related increases in cardiac and stroke volume indices among patients with chronic heart failure and elevated left ventricular filling pressure. However, it induces dose-related reductions in cardiac and stroke volume indices among normal subjects as well as patients with heart failure and normal left ventricular filling pressures.

KW - Congestive heart failure

KW - Continuous positive airway pressure

KW - Haemodynamics

UR - http://www.scopus.com/inward/record.url?scp=0028820959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028820959&partnerID=8YFLogxK

M3 - Article

VL - 88

SP - 173

EP - 178

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 2

ER -