Haemophilus influenzae type b disease after rifampin prophylaxis in a day care center

possible reasons for its failure

T. V. Murphy, G. H. McCracken, B. S. Moore, P. A. Gulig, E. J. Hansen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Five infants enrolled in a day care center (DCC) developed invasive disease due to Haemophilus influenzae type b during a 25-week period. The isolates from four patients had identical outer membrane proteins and were biptype 1. Although rifampin prophylaxis was recommended on two different occasions, retrospective surveys demonstrated that 39 and 60%, respectively, of infants failed to receive the agent for various reasons. Pharyngeal cultures were obtained from infants, their families and DCC staff after prophylaxis was given the second time. Forty-seven % of DCC infants had positive cultures, and 59% of their households had at least one carrier of the invasive strain. Rifampin prophylaxis administered a third time to infants and members of their households was unsuccessful in eradicating the invasive Haemophilus influenze type b strain from DCC infants. The possible reasons for failure or rifampin in this DCC outbreak included incomplete understanding by physicians and health department officials of the factors affecting a DCC outbreak of Haemophilus influenzae type b disease and failure properly to implement rifampin prophylaxis to all contacts and the index cases.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalPediatric Infectious Disease
Volume2
Issue number3
StatePublished - 1983

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Haemophilus influenzae type b
Rifampin
Disease Outbreaks
Haemophilus
Membrane Proteins
Physicians
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haemophilus influenzae type b disease after rifampin prophylaxis in a day care center : possible reasons for its failure. / Murphy, T. V.; McCracken, G. H.; Moore, B. S.; Gulig, P. A.; Hansen, E. J.

In: Pediatric Infectious Disease, Vol. 2, No. 3, 1983, p. 193-198.

Research output: Contribution to journalArticle

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