Half-life analysis of pancreas and kidney transplants

Carlos E. Marroquin, Erick B. Edwards, Bradley H. Collins, Dev M. Desai, Janet E. Tuttle-Newhall, Paul C. Kuo

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Although graft and patient survival data are available for pancreas and kidney transplants, they are rarely reported in terms of half-life. Our aim was to determine whether a more relevant measure of outcome is patient and allograft half-life. Using the data from the Organ Procurement and Transplantation Network Registry on kidney and pancreas transplants from January 1988 to December 1996, patient and graft half-life and 95% confidence intervals were calculated and demographic variables compared. No significant differences were found between demographic variables. Kidneys transplanted in diabetics as a simultaneous kidney-pancreas (SPK) fared better than diabetics receiving a kidney alone (9.6 vs. 6.3 years). Pancreatic graft survival in an SPK pair was better than pancreas after kidney transplant or pancreas transplant alone (11.2 vs. 2.5 years). Because kidney and pancreatic grafts have a longer half-life when transplanted with their mate grafts, we should consider the relative benefits of SPKs over pancreas after kidney transplant or pancreas transplant alone to limit the loss of precious resources.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalTransplantation
Volume80
Issue number2
DOIs
StatePublished - Jul 27 2005

Keywords

  • Allograft survival
  • Half-life
  • Pancreas after kidney
  • Pancreas transplant alone
  • Patient survival
  • Simultaneous kidney-pancreas transplant

ASJC Scopus subject areas

  • Transplantation

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    Marroquin, C. E., Edwards, E. B., Collins, B. H., Desai, D. M., Tuttle-Newhall, J. E., & Kuo, P. C. (2005). Half-life analysis of pancreas and kidney transplants. Transplantation, 80(2), 272-275. https://doi.org/10.1097/01.TP.0000165094.94020.03