Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection

J. W. Streilein, P. R. Bergstresser

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derived with the relevant hapten, but only if the hapten is applied while the graft is 'healing in'. This model system was used to demonstrate that the hapten-specific immune effectors reponsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity.

Original languageEnglish (US)
Pages (from-to)1354-1359
Number of pages6
JournalJournal of Experimental Medicine
Volume157
Issue number4
StatePublished - 1983

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Histocompatibility Antigens
Haptens
Graft Rejection
Transplants
Immunity
Transplantation
Skin

ASJC Scopus subject areas

  • Immunology

Cite this

Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection. / Streilein, J. W.; Bergstresser, P. R.

In: Journal of Experimental Medicine, Vol. 157, No. 4, 1983, p. 1354-1359.

Research output: Contribution to journalArticle

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