TY - JOUR
T1 - Haptoglobin phenotype, angiogenic factors, and preeclampsia risk
AU - Weissgerber, Tracey L.
AU - Roberts, James M.
AU - Jeyabalan, Arun
AU - Powers, Robert W.
AU - Lee, Minjae
AU - Datwyler, Saul A.
AU - Gandley, Robin E.
N1 - Funding Information:
This work was supported by National Institutes of Health P01 HD030367 . Measurement of soluble fms-like tyrosine kinase 1 and placental growth factor was funded by Abbott Laboratories. T.L.W. was supported by a Canadian Institute of Health Research Fellowship, and the Amy Roberts Health Promotion Research Award.
PY - 2012/4
Y1 - 2012/4
N2 - OBJECTIVE: We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF). STUDY DESIGN: Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. RESULTS: Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes. CONCLUSION: Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.
AB - OBJECTIVE: We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF). STUDY DESIGN: Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. RESULTS: Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes. CONCLUSION: Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.
KW - angiogenesis
KW - gestational hypertension
KW - haptoglobin phenotype
KW - preeclampsia
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U2 - 10.1016/j.ajog.2012.01.009
DO - 10.1016/j.ajog.2012.01.009
M3 - Article
C2 - 22340942
AN - SCOPUS:84862814752
SN - 0002-9378
VL - 206
SP - 358.e10-358.e18
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -