Haptoglobin phenotype, angiogenic factors, and preeclampsia risk

Tracey L. Weissgerber, James M. Roberts, Arun Jeyabalan, Robert W. Powers, Minjae Lee, Saul A. Datwyler, Robin E. Gandley

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


OBJECTIVE: We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF). STUDY DESIGN: Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. RESULTS: Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes. CONCLUSION: Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.

Original languageEnglish (US)
Pages (from-to)358.e10-358.e18
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Apr 2012
Externally publishedYes


  • angiogenesis
  • gestational hypertension
  • haptoglobin phenotype
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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