Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors

H. Paul Martinez, Yuko Kono, Sarah L. Blair, Sergio Sandoval, Jessica Wang-Rodriguez, Robert F. Mattrey, Andrew C. Kummel, William C. Trogler

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Hollow hard shell particles of 200 nm and 2 micron diameter with a 10 nm thick porous silica shell have been synthesized using polystyrene templates and a sol-gel process. The template ensures than the hollow particles are monodispersed, while the charged silica surface ensures that they remain suspended in solution for weeks. When filled with perfluorocarbon gas, the particles behave as an efficient contrast agent for colour Doppler ultrasound imaging in human breast tissue. The silica shell provides unique properties compared to conventional soft shell particles employed as ultrasound contrast agents: uniform size control, strong adsorption to tissue and cells immobilizing particles at the tissue injection site, a long imaging lifetime, and a silica surface that can be easily modified with biotargeting ligands or small molecules to adjust the surface charge and polarity.

Original languageEnglish (US)
Pages (from-to)266-270
Number of pages5
JournalMedChemComm
Volume1
Issue number4
DOIs
StatePublished - Oct 1 2010

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Doppler Ultrasonography
Silicon Dioxide
Tumors
Color
Gases
Ultrasonics
Imaging techniques
Tissue
Contrast Media
Neoplasms
Fluorocarbons
Polystyrenes
Polymethyl Methacrylate
Surface charge
Sol-gel process
Adsorption
Breast
Gels
Ligands
Injections

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Martinez, H. P., Kono, Y., Blair, S. L., Sandoval, S., Wang-Rodriguez, J., Mattrey, R. F., ... Trogler, W. C. (2010). Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors. MedChemComm, 1(4), 266-270. https://doi.org/10.1039/c0md00139b

Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors. / Martinez, H. Paul; Kono, Yuko; Blair, Sarah L.; Sandoval, Sergio; Wang-Rodriguez, Jessica; Mattrey, Robert F.; Kummel, Andrew C.; Trogler, William C.

In: MedChemComm, Vol. 1, No. 4, 01.10.2010, p. 266-270.

Research output: Contribution to journalArticle

Martinez, HP, Kono, Y, Blair, SL, Sandoval, S, Wang-Rodriguez, J, Mattrey, RF, Kummel, AC & Trogler, WC 2010, 'Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors', MedChemComm, vol. 1, no. 4, pp. 266-270. https://doi.org/10.1039/c0md00139b
Martinez, H. Paul ; Kono, Yuko ; Blair, Sarah L. ; Sandoval, Sergio ; Wang-Rodriguez, Jessica ; Mattrey, Robert F. ; Kummel, Andrew C. ; Trogler, William C. / Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors. In: MedChemComm. 2010 ; Vol. 1, No. 4. pp. 266-270.
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