Harmful effects of NSAIDs among patients with hypertension and coronary artery disease

Anthony A. Bavry, Asma Khaliq, Yan Gong, Eileen M. Handberg, Rhonda M. Cooper-Dehoff, Carl J. Pepine

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Background: There is limited information about the safety of chronic nonsteroidal anti-inflammatory drugs (NSAIDs) in hypertensive patients with coronary artery disease. Methods: This was a post hoc analysis from the INternational VErapamil Trandolapril STudy (INVEST), which enrolled patients with hypertension and coronary artery disease. At each visit, patients were asked by the local site investigator if they were currently taking NSAIDs. Patients who reported NSAID use at every visit were defined as chronic NSAID users, while all others (occasional or never users) were defined as nonchronic NSAID users. The primary composite outcome was all-cause death, nonfatal myocardial infarction, or nonfatal stroke. Cox regression was used to construct a multivariate analysis for the primary outcome. Results: There were 882 chronic NSAID users and 21,694 nonchronic NSAID users (n = 14,408 for never users and n = 7286 for intermittent users). At a mean follow-up of 2.7 years, the primary outcome occurred at a rate of 4.4 events per 100 patient-years in the chronic NSAID group, versus 3.7 events per 100 patient-years in the nonchronic NSAID group (adjusted hazard ratio [HR] 1.47; 95% confidence interval [CI], 1.19-1.82; P = .0003). This was due to an increase in cardiovascular mortality (adjusted HR 2.26; 95% CI, 1.70-3.01; P <.0001). Conclusion: Among hypertensive patients with coronary artery disease, chronic self-reported use of NSAIDs was associated with an increased risk of adverse events during long-term follow-up.

Original languageEnglish (US)
Pages (from-to)614-620
Number of pages7
JournalAmerican Journal of Medicine
Volume124
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Coronary artery disease
  • Hypertension
  • Myocardial infarction
  • Nonsteroidal anti-inflammatory drugs
  • NSAIDs

ASJC Scopus subject areas

  • Medicine(all)

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