Harmonization of cortical thickness measurements across scanners and sites

Jean Philippe Fortin, Nicholas Cullen, Yvette I. Sheline, Warren D. Taylor, Irem Aselcioglu, Philip A. Cook, Phil Adams, Crystal Cooper, Maurizio Fava, Patrick J. McGrath, Melvin McInnis, Mary L. Phillips, Madhukar H. Trivedi, Myrna M. Weissman, Russell T. Shinohara

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

With the proliferation of multi-site neuroimaging studies, there is a greater need for handling non-biological variance introduced by differences in MRI scanners and acquisition protocols. Such unwanted sources of variation, which we refer to as “scanner effects”, can hinder the detection of imaging features associated with clinical covariates of interest and cause spurious findings. In this paper, we investigate scanner effects in two large multi-site studies on cortical thickness measurements across a total of 11 scanners. We propose a set of tools for visualizing and identifying scanner effects that are generalizable to other modalities. We then propose to use ComBat, a technique adopted from the genomics literature and recently applied to diffusion tensor imaging data, to combine and harmonize cortical thickness values across scanners. We show that ComBat removes unwanted sources of scan variability while simultaneously increasing the power and reproducibility of subsequent statistical analyses. We also show that ComBat is useful for combining imaging data with the goal of studying life-span trajectories in the brain.

Original languageEnglish (US)
Pages (from-to)104-120
Number of pages17
JournalNeuroImage
Volume167
DOIs
StatePublished - Feb 15 2018

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Diffusion Tensor Imaging
Genomics
Neuroimaging
Brain

Keywords

  • ComBat
  • Cortical thickness
  • Harmonization
  • Inter-scanner
  • Multi-site

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Fortin, J. P., Cullen, N., Sheline, Y. I., Taylor, W. D., Aselcioglu, I., Cook, P. A., ... Shinohara, R. T. (2018). Harmonization of cortical thickness measurements across scanners and sites. NeuroImage, 167, 104-120. https://doi.org/10.1016/j.neuroimage.2017.11.024

Harmonization of cortical thickness measurements across scanners and sites. / Fortin, Jean Philippe; Cullen, Nicholas; Sheline, Yvette I.; Taylor, Warren D.; Aselcioglu, Irem; Cook, Philip A.; Adams, Phil; Cooper, Crystal; Fava, Maurizio; McGrath, Patrick J.; McInnis, Melvin; Phillips, Mary L.; Trivedi, Madhukar H.; Weissman, Myrna M.; Shinohara, Russell T.

In: NeuroImage, Vol. 167, 15.02.2018, p. 104-120.

Research output: Contribution to journalArticle

Fortin, JP, Cullen, N, Sheline, YI, Taylor, WD, Aselcioglu, I, Cook, PA, Adams, P, Cooper, C, Fava, M, McGrath, PJ, McInnis, M, Phillips, ML, Trivedi, MH, Weissman, MM & Shinohara, RT 2018, 'Harmonization of cortical thickness measurements across scanners and sites', NeuroImage, vol. 167, pp. 104-120. https://doi.org/10.1016/j.neuroimage.2017.11.024
Fortin JP, Cullen N, Sheline YI, Taylor WD, Aselcioglu I, Cook PA et al. Harmonization of cortical thickness measurements across scanners and sites. NeuroImage. 2018 Feb 15;167:104-120. https://doi.org/10.1016/j.neuroimage.2017.11.024
Fortin, Jean Philippe ; Cullen, Nicholas ; Sheline, Yvette I. ; Taylor, Warren D. ; Aselcioglu, Irem ; Cook, Philip A. ; Adams, Phil ; Cooper, Crystal ; Fava, Maurizio ; McGrath, Patrick J. ; McInnis, Melvin ; Phillips, Mary L. ; Trivedi, Madhukar H. ; Weissman, Myrna M. ; Shinohara, Russell T. / Harmonization of cortical thickness measurements across scanners and sites. In: NeuroImage. 2018 ; Vol. 167. pp. 104-120.
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