Harnessing regenerative and immunomodulatory properties of mesenchymal stem cells in transplantation medicine

Jaehyup Kim, Peiman Hematti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal stem cells (MSCs) are an ubiquitous type of cell present in almost all human tissues. Clinical utilization of these cells was initially based on their bone marrow (BM) supportive activity and the ability to repair bone and cartilage. However, more recent data indicate that MSCs modulate immunological responses through their interactions with various immune cells and participate in tissue repair via paracrine effects, such as secretion of cytokines and growth factors. Currently, MSCs derived from BM, and to a lesser extent from other tissues, are being investigated in a wide variety of clinical trials, including in the field of solid organ transplantation. Numerous desirable properties of MSCs such as their ease of ex vivo production, impressive record of safety in a wide variety of clinical scenarios, and intriguing tissue regenerative and immunomodulatory properties combined with the promising results reported so far make them a prime candidate for further investigation.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages163-175
Number of pages13
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Immune modulation
  • Mesenchymal stem cells
  • Regenerative medicine
  • Transplantation medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kim, J., & Hematti, P. (2014). Harnessing regenerative and immunomodulatory properties of mesenchymal stem cells in transplantation medicine. In Regenerative Medicine Applications in Organ Transplantation (pp. 163-175). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00012-4