Harnessing the nuclear receptor PPARγ to inhibit the growth of lung adenocarcinoma by rewiring metabolic circuitries

Paul Yenerall, Ralf Kittler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Altered metabolism and nuclear receptor activity have been reported in various cancer types. Here, we discuss our recent finding that the metabolic state of lung adenocarcinoma cells expressing the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) can be modulated by thiazolidinediones, culminating in accumulation of reactive oxygen species and decreased proliferation.

Original languageEnglish (US)
Article numbere980660
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 3 2015

Keywords

  • lung cancer
  • metabolism
  • nuclear receptor
  • PPARγ
  • targeted therapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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