Abstract
Altered metabolism and nuclear receptor activity have been reported in various cancer types. Here, we discuss our recent finding that the metabolic state of lung adenocarcinoma cells expressing the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) can be modulated by thiazolidinediones, culminating in accumulation of reactive oxygen species and decreased proliferation.
Original language | English (US) |
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Article number | e980660 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Apr 3 2015 |
Keywords
- PPARγ
- lung cancer
- metabolism
- nuclear receptor
- targeted therapy
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research