HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

Joshua J. Gruber, Benjamin Geller, Andrew M. Lipchik, Justin Chen, Ameen A. Salahudeen, Ashwin N. Ram, James M. Ford, Calvin J. Kuo, Michael P. Snyder

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Nascent histone H4 is acetylated by cytoplasmic histone acetyltransferase 1 (HAT1) and then de-acetylated after chromatin insertion, releasing free acetate. Gruber et al. discover that HAT1 also binds an acetate-sensitive promoter element in histone H4 genes. Therefore, histone production and acetylation are linked by HAT1 to drive cell division via acetyl-Co-A regeneration.

Original languageEnglish (US)
Pages (from-to)711-724.e5
JournalMolecular cell
Volume75
Issue number4
DOIs
StatePublished - Aug 22 2019
Externally publishedYes

Keywords

  • H3K9Ac
  • H4K12Ac
  • H4K5Ac
  • HAT1
  • acetate
  • acetyl-Co-A
  • cancer metabolism
  • chromatin replication
  • histone H4
  • nutrient sensing

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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