@article{982239006b8744a5b30e4a4066126c2a,
title = "HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding",
abstract = "Nascent histone H4 is acetylated by cytoplasmic histone acetyltransferase 1 (HAT1) and then de-acetylated after chromatin insertion, releasing free acetate. Gruber et al. discover that HAT1 also binds an acetate-sensitive promoter element in histone H4 genes. Therefore, histone production and acetylation are linked by HAT1 to drive cell division via acetyl-Co-A regeneration.",
keywords = "H3K9Ac, H4K12Ac, H4K5Ac, HAT1, acetate, acetyl-Co-A, cancer metabolism, chromatin replication, histone H4, nutrient sensing",
author = "Gruber, {Joshua J.} and Benjamin Geller and Lipchik, {Andrew M.} and Justin Chen and Salahudeen, {Ameen A.} and Ram, {Ashwin N.} and Ford, {James M.} and Kuo, {Calvin J.} and Snyder, {Michael P.}",
note = "Funding Information: We wish to thank Brandon Aubrey at Dana-Farber Cancer Institute and members of the Snyder laboratory for helpful discussions and constructive criticism of this work. Funding information is as follows: this work used the Genome Sequencing Service Center by Stanford Center for Genomics and Personalized Medicine Sequencing Center, supported by the NIH grant award S10OD020141 . J.J.G. was supported by fellowships from the Jane Coffin Childs Memorial Fund for Medical Research , Stanford Cancer Institute and Susan G. Komen Foundation (PDF17483383), as well as funding from ASCO , the Conquer Cancer Foundation , and the Breast Cancer Research Foundation . M.P.S. is supported by grants from the NIH including a Centers of Excellence in Genomic Science award ( 5P50HG00773502 ). Funding Information: We wish to thank Brandon Aubrey at Dana-Farber Cancer Institute and members of the Snyder laboratory for helpful discussions and constructive criticism of this work. Funding information is as follows: this work used the Genome Sequencing Service Center by Stanford Center for Genomics and Personalized Medicine Sequencing Center, supported by the NIH grant award S10OD020141. J.J.G. was supported by fellowships from the Jane Coffin Childs Memorial Fund for Medical Research, Stanford Cancer Institute and Susan G. Komen Foundation (PDF17483383), as well as funding from ASCO, the Conquer Cancer Foundation, and the Breast Cancer Research Foundation. M.P.S. is supported by grants from the NIH including a Centers of Excellence in Genomic Science award (5P50HG00773502). Conceptualization, J.J.G. B.G. J.C. A.M.L. and M.P.S.; Investigation, J.J.G. B.G. and A.N.R.; Validation, J.J.G. B.G. and M.P.S.; Formal Analysis, J.J.G.; Resources, M.P.S.; Writing, J.J.G. J.C. and M.P.S.; Visualization, J.J.G. B.G. J.C. and A.M.L.; Supervision: J.M.F. and M.P.S.; Funding Acquisition, J.J.G. and M.P.S. M.P.S. is a founder and member of the science advisory board of Personalis, SensOmics, January, and Qbio and a science advisory board member of Genapsys. J.J.G and M.P.S. are supported by a grant from Curis, Inc. Funding Information: M.P.S. is a founder and member of the science advisory board of Personalis, SensOmics, January, and Qbio and a science advisory board member of Genapsys. J.J.G and M.P.S. are supported by a grant from Curis, Inc. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = aug,
day = "22",
doi = "10.1016/j.molcel.2019.05.034",
language = "English (US)",
volume = "75",
pages = "711--724.e5",
journal = "Molecular cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",
}