Hayflick, his limit, and cellular ageing

Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent - a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalNature Reviews Molecular Cell Biology
Volume1
Issue number1
StatePublished - Oct 2000

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Cell Aging

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Hayflick, his limit, and cellular ageing. / Shay, Jerry W.; Wright, Woodring E.

In: Nature Reviews Molecular Cell Biology, Vol. 1, No. 1, 10.2000, p. 72-76.

Research output: Contribution to journalArticle

Shay, Jerry W. ; Wright, Woodring E. / Hayflick, his limit, and cellular ageing. In: Nature Reviews Molecular Cell Biology. 2000 ; Vol. 1, No. 1. pp. 72-76.
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