Hayflick, his limit, and cellular ageing

Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journalReview article

362 Scopus citations

Abstract

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent - a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalNature Reviews Molecular Cell Biology
Volume1
Issue number1
DOIs
StatePublished - Oct 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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