HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors

Makoto Taniguchi, Maria B. Carreira, Yonatan A. Cooper, Ana Clara Bobadilla, Jasper A. Heinsbroek, Nobuya Koike, Erin B. Larson, Evan A. Balmuth, Brandon W. Hughes, Rachel D. Penrod, Jaswinder Kumar, Laura N. Smith, Daniel Guzman, Joseph S. Takahashi, Tae Kyung Kim, Peter W. Kalivas, David W. Self, Yingxi Lin, Christopher W. Cowan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Individuals suffering from substance-use disorders develop strong associations between the drug's rewarding effects and environmental cues, creating powerful, enduring triggers for relapse. We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression. Exposure to cocaine and the test chamber induced rapid and transient NPAS4 expression in a small subpopulation of FOS-positive neurons in the NAc. Conditional deletion of Npas4 in the NAc significantly reduced cocaine conditioned place preference and delayed learning of the drug-reinforced action during cocaine self-administration, without affecting cue-induced reinstatement of drug seeking. These data suggest that HDAC5 and NPAS4 in the NAc are critically involved in reward-relevant learning and memory processes and that nuclear HDAC5 limits reinstatement of drug seeking independent of NPAS4.

Original languageEnglish (US)
Pages (from-to)130-144
Number of pages15
JournalNeuron
Volume96
Issue number1
DOIs
StatePublished - Sep 27 2017

Fingerprint

Histone Deacetylases
Nucleus Accumbens
Cocaine
Self Administration
Genes
Reward
Pharmaceutical Preparations
Cues
Learning
Recurrence
Substance-Related Disorders
Neurons

Keywords

  • ChIP-seq
  • chromatin immunoprecipitation
  • cocaine addiction
  • conditioned place preference
  • drug self-administration
  • HDAC5
  • histone deacetylase
  • NPAS4
  • nucleus accumbens
  • reinstatement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Taniguchi, M., Carreira, M. B., Cooper, Y. A., Bobadilla, A. C., Heinsbroek, J. A., Koike, N., ... Cowan, C. W. (2017). HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron, 96(1), 130-144. https://doi.org/10.1016/j.neuron.2017.09.015

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. / Taniguchi, Makoto; Carreira, Maria B.; Cooper, Yonatan A.; Bobadilla, Ana Clara; Heinsbroek, Jasper A.; Koike, Nobuya; Larson, Erin B.; Balmuth, Evan A.; Hughes, Brandon W.; Penrod, Rachel D.; Kumar, Jaswinder; Smith, Laura N.; Guzman, Daniel; Takahashi, Joseph S.; Kim, Tae Kyung; Kalivas, Peter W.; Self, David W.; Lin, Yingxi; Cowan, Christopher W.

In: Neuron, Vol. 96, No. 1, 27.09.2017, p. 130-144.

Research output: Contribution to journalArticle

Taniguchi, M, Carreira, MB, Cooper, YA, Bobadilla, AC, Heinsbroek, JA, Koike, N, Larson, EB, Balmuth, EA, Hughes, BW, Penrod, RD, Kumar, J, Smith, LN, Guzman, D, Takahashi, JS, Kim, TK, Kalivas, PW, Self, DW, Lin, Y & Cowan, CW 2017, 'HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors', Neuron, vol. 96, no. 1, pp. 130-144. https://doi.org/10.1016/j.neuron.2017.09.015
Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N et al. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. 2017 Sep 27;96(1):130-144. https://doi.org/10.1016/j.neuron.2017.09.015
Taniguchi, Makoto ; Carreira, Maria B. ; Cooper, Yonatan A. ; Bobadilla, Ana Clara ; Heinsbroek, Jasper A. ; Koike, Nobuya ; Larson, Erin B. ; Balmuth, Evan A. ; Hughes, Brandon W. ; Penrod, Rachel D. ; Kumar, Jaswinder ; Smith, Laura N. ; Guzman, Daniel ; Takahashi, Joseph S. ; Kim, Tae Kyung ; Kalivas, Peter W. ; Self, David W. ; Lin, Yingxi ; Cowan, Christopher W. / HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. In: Neuron. 2017 ; Vol. 96, No. 1. pp. 130-144.
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