HDL efflux capacity, HDL particle size, & high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: The Chicago Healthy Aging Study

R. Kannan Mutharasan, C. Shad Thaxton, Jarett Berry, Martha L. Daviglus, Chun Yuan, Jie Sun, Colby Ayers, Donald M. Lloyd-Jones, John T. Wilkins

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

HDL efflux capacity and HDL particle size are associated with atherosclerotic CVD (ASCVD) events in middle-Aged individuals; however, it is unclear whether these associations are present in older adults. We sampled 402 Chicago Healthy Aging Study participants who underwent a dedicated carotid MRI assessment for lipid-rich necrotic core (LRNC) plaque. We measured HDL particle size, HDL particle number, and LDL particle number with NMR spectroscopy, as well as HDL efflux capacity. We quantified the associations between HDL particle size and HDL efflux using adjusted linear regression models. We quantified associations between the presence of LRNC and HDL and LDL particle number, HDL particle size, and HDL efflux capacity using adjusted logistic regression models. HDL efflux capacity was directly associated with large (? = 0.037, P < 0.001) and medium (? = 0.0065, P = 0.002) HDL particle concentration and inversely associated with small (? = ?0.0049, P = 0.018) HDL particle concentration in multivariable adjusted models. HDL efflux capacity and HDL particle number were inversely associated with prevalent LRNC plaque in unadjusted models (odds ratio: 0.5; 95% confidence interval: 0.26, 0.96), but not after multivariable adjustment. HDL particle size was not associated with prevalent LRNC. HDL particle size was significantly associated with HDL efflux capacity, suggesting that differences in HDL efflux capacity may be due to structural differences in HDL particles. Future research is needed to determine whether HDL efflux is a marker of ASCVD risk in older populations.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalJournal of Lipid Research
Volume58
Issue number3
DOIs
StatePublished - 2017

Keywords

  • High density lipoprotein/structure
  • Lipid/efflux
  • Low density lipoprotein

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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    Mutharasan, R. K., Thaxton, C. S., Berry, J., Daviglus, M. L., Yuan, C., Sun, J., Ayers, C., Lloyd-Jones, D. M., & Wilkins, J. T. (2017). HDL efflux capacity, HDL particle size, & high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: The Chicago Healthy Aging Study. Journal of Lipid Research, 58(3), 600-606. https://doi.org/10.1194/jlr.P069039