Head and Neck Cancer Detection in Digitized Whole-Slide Histology Using Convolutional Neural Networks

Martin Halicek, Maysam Shahedi, James V. Little, Amy Y. Chen, Larry L. Myers, Baran D. Sumer, Baowei Fei

Research output: Contribution to journalArticle

Abstract

Primary management for head and neck cancers, including squamous cell carcinoma (SCC), involves surgical resection with negative cancer margins. Pathologists guide surgeons during these operations by detecting cancer in histology slides made from the excised tissue. In this study, 381 digitized, histological whole-slide images (WSI) from 156 patients with head and neck cancer were used to train, validate, and test an inception-v4 convolutional neural network. The proposed method is able to detect and localize primary head and neck SCC on WSI with an AUC of 0.916 for patients in the SCC testing group and 0.954 for patients in the thyroid carcinoma testing group. Moreover, the proposed method is able to diagnose WSI with cancer versus normal slides with an AUC of 0.944 and 0.995 for the SCC and thyroid carcinoma testing groups, respectively. For comparison, we tested the proposed, diagnostic method on an open-source dataset of WSI from sentinel lymph nodes with breast cancer metastases, CAMELYON 2016, to obtain patch-based cancer localization and slide-level cancer diagnoses. The experimental design yields a robust method with potential to help create a tool to increase efficiency and accuracy of pathologists detecting head and neck cancers in histological images.

Original languageEnglish (US)
Article number14043
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Head and Neck Neoplasms
Histology
Squamous Cell Carcinoma
Neoplasms
Thyroid Neoplasms
Area Under Curve
Research Design
Breast Neoplasms
Neoplasm Metastasis
Pathologists

ASJC Scopus subject areas

  • General

Cite this

Head and Neck Cancer Detection in Digitized Whole-Slide Histology Using Convolutional Neural Networks. / Halicek, Martin; Shahedi, Maysam; Little, James V.; Chen, Amy Y.; Myers, Larry L.; Sumer, Baran D.; Fei, Baowei.

In: Scientific reports, Vol. 9, No. 1, 14043, 01.12.2019.

Research output: Contribution to journalArticle

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