Head and Neck Cytopathology: Human Papillomavirus-Positive Carcinomas, Including Diagnostic Updates, Testing Modalities, and Recommendations

Emilio Madrigal, Justin A. Bishop, William C. Faquin

Research output: Contribution to journalReview article

3 Scopus citations


Oropharyngeal squamous cell carcinoma caused by transcriptionally active human papillomavirus (HPV) is now well established as a unique form of head and neck cancer. Given the high frequency of metastasis to cervical lymph nodes by HPV-positive oropharyngeal squamous cell carcinomas, fine-needle aspiration (FNA) represents a widely accepted method for the sampling and diagnosis of these cancers. The recently published College of American Pathologists Guideline (2017) provides recommendations for the effective performance and interpretation of high-risk (HR) HPV testing in head and neck squamous cell carcinoma (HNSCC), including testing on FNA samples of metastatic HNSCC to cervical lymph nodes. There is a wide range of options available for HR-HPV testing in cytologic specimens.

Original languageEnglish (US)
Pages (from-to)501-514
Number of pages14
JournalSurgical Pathology Clinics
Issue number3
StatePublished - Sep 1 2018



  • FNA
  • Head and neck cytopathology
  • Head and neck squamous cell carcinoma
  • Human papillomavirus

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

Cite this