Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial

J. I. Isenberg, W. L. Peterson, J. D. Elashoff, M. A. Sandersfeld, T. J. Reedy, A. F. Ippoliti, G. M. Van Deventer, H. Frankl, G. F. Longstreth, D. S. Anderson

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

We conducted a 12-week, double-blind, randomized, placebo-controlled trial to determine whether cimetidine (300 mg with meals and at bedtime) or a convenient, liquid aluminum-magnesium antacid regimen (15 ml one hour after meals and at bedtime) would expedite healing or relief of symptoms in patients with benign gastric ulcer. Of the 101 patients who completed the trial according to protocol, 32 received the antacid, 36 cimetidine, and 33 placebo. At 4, 8, and 12 weeks after entry, ulcers had healed in a larger percentage of patients treated with cimetidine than of those treated with placebo: 53, 86, and 89 per cent of the cimetidine group versus 26, 58, and 70 per cent of the placebo group (P = 0.02, 0.01, 0.05), respectively. Healing at the three intervals had occurred in 38, 70, and 84 per cent, respectively, of the antacid-treated patients. Neither cimetidine nor antacid was more effective than placebo in relieving symptoms. The presence or absence of symptoms during the fourth and eighth treatment weeks was a poor predictor of the presence or absence of an ulcer crater. We conclude that cimetidine significantly hastens the healing of benign gastric ulcer.

Original languageEnglish (US)
Pages (from-to)1319-1324
Number of pages6
JournalNew England Journal of Medicine
Volume308
Issue number22
StatePublished - 1983

Fingerprint

Antacids
Cimetidine
Stomach Ulcer
Randomized Controlled Trials
Placebos
Ulcer
Meals
Aluminum
Magnesium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Isenberg, J. I., Peterson, W. L., Elashoff, J. D., Sandersfeld, M. A., Reedy, T. J., Ippoliti, A. F., ... Anderson, D. S. (1983). Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. New England Journal of Medicine, 308(22), 1319-1324.

Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. / Isenberg, J. I.; Peterson, W. L.; Elashoff, J. D.; Sandersfeld, M. A.; Reedy, T. J.; Ippoliti, A. F.; Van Deventer, G. M.; Frankl, H.; Longstreth, G. F.; Anderson, D. S.

In: New England Journal of Medicine, Vol. 308, No. 22, 1983, p. 1319-1324.

Research output: Contribution to journalArticle

Isenberg, JI, Peterson, WL, Elashoff, JD, Sandersfeld, MA, Reedy, TJ, Ippoliti, AF, Van Deventer, GM, Frankl, H, Longstreth, GF & Anderson, DS 1983, 'Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial', New England Journal of Medicine, vol. 308, no. 22, pp. 1319-1324.
Isenberg JI, Peterson WL, Elashoff JD, Sandersfeld MA, Reedy TJ, Ippoliti AF et al. Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. New England Journal of Medicine. 1983;308(22):1319-1324.
Isenberg, J. I. ; Peterson, W. L. ; Elashoff, J. D. ; Sandersfeld, M. A. ; Reedy, T. J. ; Ippoliti, A. F. ; Van Deventer, G. M. ; Frankl, H. ; Longstreth, G. F. ; Anderson, D. S. / Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. In: New England Journal of Medicine. 1983 ; Vol. 308, No. 22. pp. 1319-1324.
@article{9217dd61113b4df6bf73424bc3e14fae,
title = "Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial",
abstract = "We conducted a 12-week, double-blind, randomized, placebo-controlled trial to determine whether cimetidine (300 mg with meals and at bedtime) or a convenient, liquid aluminum-magnesium antacid regimen (15 ml one hour after meals and at bedtime) would expedite healing or relief of symptoms in patients with benign gastric ulcer. Of the 101 patients who completed the trial according to protocol, 32 received the antacid, 36 cimetidine, and 33 placebo. At 4, 8, and 12 weeks after entry, ulcers had healed in a larger percentage of patients treated with cimetidine than of those treated with placebo: 53, 86, and 89 per cent of the cimetidine group versus 26, 58, and 70 per cent of the placebo group (P = 0.02, 0.01, 0.05), respectively. Healing at the three intervals had occurred in 38, 70, and 84 per cent, respectively, of the antacid-treated patients. Neither cimetidine nor antacid was more effective than placebo in relieving symptoms. The presence or absence of symptoms during the fourth and eighth treatment weeks was a poor predictor of the presence or absence of an ulcer crater. We conclude that cimetidine significantly hastens the healing of benign gastric ulcer.",
author = "Isenberg, {J. I.} and Peterson, {W. L.} and Elashoff, {J. D.} and Sandersfeld, {M. A.} and Reedy, {T. J.} and Ippoliti, {A. F.} and {Van Deventer}, {G. M.} and H. Frankl and Longstreth, {G. F.} and Anderson, {D. S.}",
year = "1983",
language = "English (US)",
volume = "308",
pages = "1319--1324",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "22",

}

TY - JOUR

T1 - Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial

AU - Isenberg, J. I.

AU - Peterson, W. L.

AU - Elashoff, J. D.

AU - Sandersfeld, M. A.

AU - Reedy, T. J.

AU - Ippoliti, A. F.

AU - Van Deventer, G. M.

AU - Frankl, H.

AU - Longstreth, G. F.

AU - Anderson, D. S.

PY - 1983

Y1 - 1983

N2 - We conducted a 12-week, double-blind, randomized, placebo-controlled trial to determine whether cimetidine (300 mg with meals and at bedtime) or a convenient, liquid aluminum-magnesium antacid regimen (15 ml one hour after meals and at bedtime) would expedite healing or relief of symptoms in patients with benign gastric ulcer. Of the 101 patients who completed the trial according to protocol, 32 received the antacid, 36 cimetidine, and 33 placebo. At 4, 8, and 12 weeks after entry, ulcers had healed in a larger percentage of patients treated with cimetidine than of those treated with placebo: 53, 86, and 89 per cent of the cimetidine group versus 26, 58, and 70 per cent of the placebo group (P = 0.02, 0.01, 0.05), respectively. Healing at the three intervals had occurred in 38, 70, and 84 per cent, respectively, of the antacid-treated patients. Neither cimetidine nor antacid was more effective than placebo in relieving symptoms. The presence or absence of symptoms during the fourth and eighth treatment weeks was a poor predictor of the presence or absence of an ulcer crater. We conclude that cimetidine significantly hastens the healing of benign gastric ulcer.

AB - We conducted a 12-week, double-blind, randomized, placebo-controlled trial to determine whether cimetidine (300 mg with meals and at bedtime) or a convenient, liquid aluminum-magnesium antacid regimen (15 ml one hour after meals and at bedtime) would expedite healing or relief of symptoms in patients with benign gastric ulcer. Of the 101 patients who completed the trial according to protocol, 32 received the antacid, 36 cimetidine, and 33 placebo. At 4, 8, and 12 weeks after entry, ulcers had healed in a larger percentage of patients treated with cimetidine than of those treated with placebo: 53, 86, and 89 per cent of the cimetidine group versus 26, 58, and 70 per cent of the placebo group (P = 0.02, 0.01, 0.05), respectively. Healing at the three intervals had occurred in 38, 70, and 84 per cent, respectively, of the antacid-treated patients. Neither cimetidine nor antacid was more effective than placebo in relieving symptoms. The presence or absence of symptoms during the fourth and eighth treatment weeks was a poor predictor of the presence or absence of an ulcer crater. We conclude that cimetidine significantly hastens the healing of benign gastric ulcer.

UR - http://www.scopus.com/inward/record.url?scp=0020581879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020581879&partnerID=8YFLogxK

M3 - Article

VL - 308

SP - 1319

EP - 1324

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 22

ER -