Healing of duodenal ulcer with an antacid regimen

W. L. Peterson, R. A L Sturdevant, H. D. Frankl, C. T. Richardson, J. I. Isenberg, J. D. Elashoff, J. Q. Sones, R. A. Gross, R. W. McCallum, J. S. Fordtran

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

To determine whether a large-dose antacid regimen is effective in promoting healing of duodenal ulcer, 74 patients with endoscopically proved duodenal ulcer completed a 28-day double-blind clinical trial comparing such a regimen with an inert placebo. The ulcer healed completely in 28 of the 36 antacid-treated as compared to 17 of the 38 placebo-treated patients (P<0.005). The antacid regimen was not more effective than placebo in relieving ulcer symptoms. Presence or absence of symptoms during the fourth treatment week was a poor predictor of presence or absence of an ulcer crater. Ulcers of placebo-treated patients who smoked cigarettes were less likely to heal than those of nonsmokers (P=0.03). Except for mild diarrhea, no side effects of the antacid regimen were observed. The authors conclude that a large-dose antacid regimen hastens the healing of duodenal ulcer.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalNew England Journal of Medicine
Volume297
Issue number7
StatePublished - 1977

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Antacids
Duodenal Ulcer
Ulcer
Placebos
Tobacco Products
Diarrhea
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peterson, W. L., Sturdevant, R. A. L., Frankl, H. D., Richardson, C. T., Isenberg, J. I., Elashoff, J. D., ... Fordtran, J. S. (1977). Healing of duodenal ulcer with an antacid regimen. New England Journal of Medicine, 297(7), 341-345.

Healing of duodenal ulcer with an antacid regimen. / Peterson, W. L.; Sturdevant, R. A L; Frankl, H. D.; Richardson, C. T.; Isenberg, J. I.; Elashoff, J. D.; Sones, J. Q.; Gross, R. A.; McCallum, R. W.; Fordtran, J. S.

In: New England Journal of Medicine, Vol. 297, No. 7, 1977, p. 341-345.

Research output: Contribution to journalArticle

Peterson, WL, Sturdevant, RAL, Frankl, HD, Richardson, CT, Isenberg, JI, Elashoff, JD, Sones, JQ, Gross, RA, McCallum, RW & Fordtran, JS 1977, 'Healing of duodenal ulcer with an antacid regimen', New England Journal of Medicine, vol. 297, no. 7, pp. 341-345.
Peterson WL, Sturdevant RAL, Frankl HD, Richardson CT, Isenberg JI, Elashoff JD et al. Healing of duodenal ulcer with an antacid regimen. New England Journal of Medicine. 1977;297(7):341-345.
Peterson, W. L. ; Sturdevant, R. A L ; Frankl, H. D. ; Richardson, C. T. ; Isenberg, J. I. ; Elashoff, J. D. ; Sones, J. Q. ; Gross, R. A. ; McCallum, R. W. ; Fordtran, J. S. / Healing of duodenal ulcer with an antacid regimen. In: New England Journal of Medicine. 1977 ; Vol. 297, No. 7. pp. 341-345.
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