Health-related quality of life in glomerular disease

CureGN Consortium

Research output: Contribution to journalArticle

Abstract

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.

Original languageEnglish (US)
Pages (from-to)1209-1224
Number of pages16
JournalKidney international
Volume95
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Quality of Life
Immunosuppression
Edema
Demography
Lipoid Nephrosis
Social Adjustment
Focal Segmental Glomerulosclerosis
Membranous Glomerulonephritis
Glomerular Filtration Rate
Immunoglobulin A
Fatigue
Longitudinal Studies
Sleep
Cohort Studies
Anxiety
Obesity
Weights and Measures
Patient Reported Outcome Measures

Keywords

  • edema
  • health-related quality of life
  • patient-reported outcomes
  • primary glomerular disease

ASJC Scopus subject areas

  • Nephrology

Cite this

Health-related quality of life in glomerular disease. / CureGN Consortium.

In: Kidney international, Vol. 95, No. 5, 01.05.2019, p. 1209-1224.

Research output: Contribution to journalArticle

CureGN Consortium. / Health-related quality of life in glomerular disease. In: Kidney international. 2019 ; Vol. 95, No. 5. pp. 1209-1224.
@article{bb200741253b4e668058d20351a2c7ad,
title = "Health-related quality of life in glomerular disease",
abstract = "There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32{\%} of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95{\%} CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.",
keywords = "edema, health-related quality of life, patient-reported outcomes, primary glomerular disease",
author = "{CureGN Consortium} and Canetta, {Pietro A.} and Troost, {Jonathan P.} and Shannon Mahoney and Kogon, {Amy J.} and Noelle Carlozzi and Bartosh, {Sharon M.} and Yi Cai and Davis, {T. Keefe} and Hilda Fernandez and Alessia Fornoni and Gbadegesin, {Rasheed A.} and Emily Herreshoff and Mahan, {John D.} and Nachman, {Patrick H.} and Selewski, {David T.} and Sethna, {Christine B.} and Tarak Srivastava and Tuttle, {Katherine R.} and Wang, {Chia shi} and Falk, {Ronald J.} and Gharavi, {Ali G.} and Gillespie, {Brenda W.} and Greenbaum, {Larry A.} and Holzman, {Lawrence B.} and Matthias Kretzler and Robinson, {Bruce M.} and Smoyer, {William E.} and Guay-Woodford, {Lisa M.} and Bryce Reeve and Gipson, {Debbie S.} and Wooin Ahn and Appel, {Gerald B.} and Revekka Babayev and Ibrahim Batal and Bomback, {Andrew S.} and Eric Brown and Campenot, {Eric S.} and Pietro Canetta and Lucrezia Carlassara and Brenda Chan and Debanjana Chatterjee and D'Agati, {Vivette D.} and Elisa Delbarba and Samriti Dogra and Bartosz Foroncewicz and Ghiggeri, {Gian Marco} and Hines, {William H.} and Husain, {S. Ali} and Jain, {Namrata G.} and Sambandam, {Kamalanathan K}",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.kint.2018.12.018",
language = "English (US)",
volume = "95",
pages = "1209--1224",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Health-related quality of life in glomerular disease

AU - CureGN Consortium

AU - Canetta, Pietro A.

AU - Troost, Jonathan P.

AU - Mahoney, Shannon

AU - Kogon, Amy J.

AU - Carlozzi, Noelle

AU - Bartosh, Sharon M.

AU - Cai, Yi

AU - Davis, T. Keefe

AU - Fernandez, Hilda

AU - Fornoni, Alessia

AU - Gbadegesin, Rasheed A.

AU - Herreshoff, Emily

AU - Mahan, John D.

AU - Nachman, Patrick H.

AU - Selewski, David T.

AU - Sethna, Christine B.

AU - Srivastava, Tarak

AU - Tuttle, Katherine R.

AU - Wang, Chia shi

AU - Falk, Ronald J.

AU - Gharavi, Ali G.

AU - Gillespie, Brenda W.

AU - Greenbaum, Larry A.

AU - Holzman, Lawrence B.

AU - Kretzler, Matthias

AU - Robinson, Bruce M.

AU - Smoyer, William E.

AU - Guay-Woodford, Lisa M.

AU - Reeve, Bryce

AU - Gipson, Debbie S.

AU - Ahn, Wooin

AU - Appel, Gerald B.

AU - Babayev, Revekka

AU - Batal, Ibrahim

AU - Bomback, Andrew S.

AU - Brown, Eric

AU - Campenot, Eric S.

AU - Canetta, Pietro

AU - Carlassara, Lucrezia

AU - Chan, Brenda

AU - Chatterjee, Debanjana

AU - D'Agati, Vivette D.

AU - Delbarba, Elisa

AU - Dogra, Samriti

AU - Foroncewicz, Bartosz

AU - Ghiggeri, Gian Marco

AU - Hines, William H.

AU - Husain, S. Ali

AU - Jain, Namrata G.

AU - Sambandam, Kamalanathan K

PY - 2019/5/1

Y1 - 2019/5/1

N2 - There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.

AB - There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.

KW - edema

KW - health-related quality of life

KW - patient-reported outcomes

KW - primary glomerular disease

UR - http://www.scopus.com/inward/record.url?scp=85062981898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062981898&partnerID=8YFLogxK

U2 - 10.1016/j.kint.2018.12.018

DO - 10.1016/j.kint.2018.12.018

M3 - Article

C2 - 30898342

AN - SCOPUS:85062981898

VL - 95

SP - 1209

EP - 1224

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 5

ER -