Heart development: Learning from mistakes

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Congenital heart disease in humans results from abnormal morphogenesis of the embryonic cardiovascular system. The characterization of mutations affecting cardiovascular development in animal models ranging from flies to mice has identified many of the key signaling molecules and transcriptional regulators of heart formation. Many of these molecules are also mutated in familial forms of human congenital heart disease. Through the use of animal models combined with analysis of human pedigrees, a molecular framework that controls formation of the vertebrate heart is beginning to emerge.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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