Heart failure and loss of metabolic control

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Heart failure is a leading cause of morbidity and mortality worldwide, currently affecting 5 million Americans. A syndrome defined on clinical terms, heart failure is the end result of events occurring in multiple heart diseases, including hypertension, myocardial infarction, genetic mutations and diabetes, and metabolic dysregulation, is a hallmark feature. Mounting evidence from clinical and preclinical studies suggests strongly that fatty acid uptake and oxidation are adversely affected, especially in end-stage heart failure. Moreover, metabolic flexibility, the heart's ability to move freely among diverse energy substrates, is impaired in heart failure. Indeed, impairment of the heart's ability to adapt to its metabolic milieu and associated metabolic derangement are important contributing factors in the heart failure pathogenesis. Elucidation of molecular mechanisms governing metabolic control in heart failure will provide critical insights into disease initiation and progression, raising the prospect of advances with clinical relevance.

Original languageEnglish (US)
Pages (from-to)302-313
Number of pages12
JournalJournal of Cardiovascular Pharmacology
Volume63
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Heart Failure
Disease Progression
Heart Diseases
Fatty Acids
Myocardial Infarction
Hypertension
Morbidity
Mutation
Mortality

Keywords

  • Heart failure
  • metabolism

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Heart failure and loss of metabolic control. / Wang, Zhao; Li, Dan L.; Hill, Joseph A.

In: Journal of Cardiovascular Pharmacology, Vol. 63, No. 4, 2014, p. 302-313.

Research output: Contribution to journalArticle

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