Heat-stress-induced changes in central venous pressure do not explain interindividual differences in orthostatic tolerance during heat stress

R. Matthew Brothers, David M. Keller, Jonathan E. Wingo, Matthew S. Ganio, Craig G. Crandall

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The extent to which heat stress compromises blood pressure control is variable among individuals, with some individuals becoming very intolerant to a hypotensive challenge, such as lower body negative pressure (LBNP) while heat stressed, while others are relatively tolerant. Heat stress itself reduces indexes of ventricular filling pressure, including central venous pressure, which may be reflective of reductions in tolerance in this thermal condition. This study tested the hypothesis that the magnitude of the reduction in central venous pressure in response to heat stress alone is related to the subsequent decrement in LBNP tolerance. In 19 subjects, central hypovolemia was imposed via LBNP to presyncope in both normothermic and heat-stress conditions. Tolerance to LBNP was quantified using a cumulative stress index (CSI), and the difference between normothermic CSI and heat-stress CSI was calculated for each individual. The eight individuals with the greatest CSI difference between normothermic and heat-stress tolerances (LargeDif), and the eight individuals with the smallest CSI difference (SmallDif), were grouped together. By design, the difference in CSI between thermal conditions was greater in the LargeDif group (969 vs. 382 mmHg × min; P < 0.001). Despite this profound difference in the effect of heat stress in decreasing LBNP tolerance between groups, coupled with no difference in the rise in core body temperatures to the heat stress (LargeDif, 1.4 ± 0.1°C vs. SmallDif, 1.4 ± 0.1°C; interaction P < 0.89), the reduction in central venous pressure during heat stress alone was similar between groups (LargeDif: 5.7 ± 1.9 mmHg vs. SmallDif: 5.2 ± 2.0 mmHg; interaction P < 0.85). Contrary to the proposed hypothesis, differences in blood pressure control during LBNP are not related to differences in the magnitude of the heat-stress-induced reductions in central venous pressure.

Original languageEnglish (US)
Pages (from-to)1283-1289
Number of pages7
JournalJournal of Applied Physiology
Volume110
Issue number5
DOIs
StatePublished - May 2011

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Central Venous Pressure
Lower Body Negative Pressure
Hot Temperature
Thermotolerance
Blood Pressure
Heat-Shock Response
Hypovolemia
Syncope
Ventricular Pressure
Body Temperature

Keywords

  • Blood pressure
  • Hemorrhage
  • Hyperthermia
  • Ventricular filling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Heat-stress-induced changes in central venous pressure do not explain interindividual differences in orthostatic tolerance during heat stress. / Brothers, R. Matthew; Keller, David M.; Wingo, Jonathan E.; Ganio, Matthew S.; Crandall, Craig G.

In: Journal of Applied Physiology, Vol. 110, No. 5, 05.2011, p. 1283-1289.

Research output: Contribution to journalArticle

Brothers, R. Matthew ; Keller, David M. ; Wingo, Jonathan E. ; Ganio, Matthew S. ; Crandall, Craig G. / Heat-stress-induced changes in central venous pressure do not explain interindividual differences in orthostatic tolerance during heat stress. In: Journal of Applied Physiology. 2011 ; Vol. 110, No. 5. pp. 1283-1289.
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