Hedgehog Signaling in Development and Cancer

Jin Jiang, Chi chung Hui

Research output: Contribution to journalReview article

727 Scopus citations

Abstract

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

Original languageEnglish (US)
Pages (from-to)801-812
Number of pages12
JournalDevelopmental Cell
Volume15
Issue number6
DOIs
StatePublished - Dec 9 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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