Helicobacter pylori as a promoter of intestinal metaplasia and gastric cancer: An alluring hypothesis in search of evidence

R. M. Genta

Research output: Contribution to journalArticle

25 Scopus citations


Objective: To examine the current evidence supporting a role for Helicobacter pylori in the genesis of intestinal metaplasia and to offer suggestions for the design of studies that could be carried out to elucidate the pathogenesis of gastric cancer. Method: Literature review. Conclusions: The epidemiologic relationship between H. pylori and gastric cancer is widely accepted; however, the sequence of events leading to the development of carcinoma is unknown. A currently accepted model is that chronic active gastritis progresses to atrophic gastritis with intestinal metaplasia, dysplasia and eventually neoplasia. The relationship between H. pylori and intestinal metaplasia remains unclear, as several studies have yielded conflicting results.

Original languageEnglish (US)
Pages (from-to)S25-S30
JournalEuropean Journal of Gastroenterology and Hepatology
Issue numberSUPPL. 1
StatePublished - Jan 1 1995



  • Gastric cancer
  • Gastric carcinoma
  • Helicobacter pylori
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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