Helicobacter pylori infection and expression of the angiogenic factor plate-derived endothelial cell growth factor by pre-neoplastic gastric mucosal lesions and gastric carcinoma

F. Francesch, R. M. Genta, A. Gasbarrini, N. Gentiloni Silveri, G. Gasbarrini, A. R. Sepulveda

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background. Expression of the angiogenic factor platelet-derived endothelial cell growth factor is induced in some gastric carcinomas. Whether angiogenesis is induced early in the development of gastric pre-neoplastic lesions and whether Helicobacter pylori infection affects platelet-derived endothelial cell growth factor expression is not known. Aim. To assess whether chronic gastritis, intestinal metaplasia, gastric dysplasia and gastric carcinomas express platelet-derived endothelial cell growth factor and whether Helicobacter pylori infection might affect the expression of platelet-derived endothelial cell growth factor in these lesions. Patients and Methods. Patients with gastric carcinomas, atrophic gastritis with associated intestinal metaplasia, dysplasia and controls without infection or carcinoma were studied. Results. Platelet-derived endothelial cell growth factor was detected by immunohistochemistry in 9 out 19 gastric carcinomas (45%). Only focal immunostaining was detected in intestinal metaplasia adjacent to dysplasia and in dysplastic cells. Of the tumours, 90% contained platelet-derived endothelial cell growth factor-positive interstitial cells. A significant correlation was found between active Helicobacter pylori infection and a larger number of platelet-derived endothelial cell growth factor-positive interstitial cells in areas of intestinal metaplasia (p<0.05). Conclusion. Helicobacter pylori infection does not influence the expression of platelet-derived endothelial cell growth factor, once gastric cancer has developed. However, Helicobacter pylori infection may increase the extension of expression of platelet-derived endothelial cell growth factor by infiltrating interstitial cells in premalignant lesions, such as intestinal metaplasia, which may help create a favourable environment for tumour development. This may possibly be due to non-specific increase in recruitment of inflammatory cells caused by Helicobacter pylori infection. Further studies, with a larger number of samples, are now needed in order to confirm this finding.

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalDigestive and Liver Disease
Volume34
Issue number9
DOIs
StatePublished - Sep 2002

Keywords

  • Angiogenic factors
  • Gastric cancer
  • Helicobacter pylori
  • Platelet-derived endothelial cell growth factor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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