Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins

Hiroyoshi Ota, Jun Nakayama, Masanobu Momose, Masayoshi Hayama, Taiji Akamatsu, Tsutomu Katsuyama, David Y. Graham, Robert M. Genta

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The protective ability of gastric mucins may depend largely on their oligosaccharide chains. We evaluated the effects of H. pylori infection on the glycosylation of gastric mucins. Gastric biopsy specimens from 20 H. pylori-infected patients before and after cure of the H. pylori infection and 8 normal uninfected volunteers were examined by immunostaining for simple mucin-type glycoproteins and blood-group-related antigens bearing type 1 chain backbone. The immunoreactivity in different gastric compartments was evaluated. Simple mucin-type glycoproteins and blood-group-related antigens were expressed in surface mucous cells. Simple mucin-type glycoproteins showed antrum-predominant expression in normal volunteers and were found in significantly fewer surface mucous cells in infected patients than in normal volunteers: their expression was restored after eradication of H. pylori. Sialyl Lewisa and Lewisb were expressed in fewer surface mucous cells after than before eradication. The patterns of glycosylation of gastric mucins vary in different gastric compartments and are reversibly altered by H. pylori infection. These alterations may affect the protective functions of gastric mucins.

Original languageEnglish (US)
Pages (from-to)419-426
Number of pages8
JournalVirchows Archiv
Volume433
Issue number5
DOIs
StatePublished - 1998

Fingerprint

Gastric Mucins
Helicobacter Infections
Glycosylation
Helicobacter pylori
Mucins
Stomach
Glycoproteins
Healthy Volunteers
Blood Group Antigens
Oligosaccharides
Biopsy

Keywords

  • Gastric mucin
  • Gastric mucosa
  • Glycoprotein
  • Helicobacter pylori
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ota, H., Nakayama, J., Momose, M., Hayama, M., Akamatsu, T., Katsuyama, T., ... Genta, R. M. (1998). Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. Virchows Archiv, 433(5), 419-426. https://doi.org/10.1007/s004280050269

Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. / Ota, Hiroyoshi; Nakayama, Jun; Momose, Masanobu; Hayama, Masayoshi; Akamatsu, Taiji; Katsuyama, Tsutomu; Graham, David Y.; Genta, Robert M.

In: Virchows Archiv, Vol. 433, No. 5, 1998, p. 419-426.

Research output: Contribution to journalArticle

Ota, H, Nakayama, J, Momose, M, Hayama, M, Akamatsu, T, Katsuyama, T, Graham, DY & Genta, RM 1998, 'Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins', Virchows Archiv, vol. 433, no. 5, pp. 419-426. https://doi.org/10.1007/s004280050269
Ota H, Nakayama J, Momose M, Hayama M, Akamatsu T, Katsuyama T et al. Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. Virchows Archiv. 1998;433(5):419-426. https://doi.org/10.1007/s004280050269
Ota, Hiroyoshi ; Nakayama, Jun ; Momose, Masanobu ; Hayama, Masayoshi ; Akamatsu, Taiji ; Katsuyama, Tsutomu ; Graham, David Y. ; Genta, Robert M. / Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. In: Virchows Archiv. 1998 ; Vol. 433, No. 5. pp. 419-426.
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