Helicobacter pylori-related disease

Guidelines for testing and treatment

Walter L. Peterson, A. Mark Fendrick, David R. Cave, David A. Peura, Susan M. Garabedian-Ruffalo, Loren Laine

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Objective: To develop practical guidelines for the treatment of patients with suspected and documented Helicobacter pylori-related gastroduodenal diseases. Methods: A panel of physicians with expertise in H pylori reviewed, critically appraised, and synthesized the literature on assigned topics and presented their overviews to the panel. Consensus was obtained in controversial areas through discussion. Results and Conclusions: The panel recommended testing for H pylori in patients with active ulcers, a history of ulcers, or gastric mucosa-associated lymphoid tissue lymphomas. Young, otherwise healthy patients with ulcerlike dyspepsia and those with a family history or fear of gastric cancer may also undergo H pylori testing. Nonendoscopic methods are preferred for H pylori diagnosis. Dual medication regimens should not be used for therapy; twice-daily triple therapy with a proton pump inhibitor or ranitidine bismuth citrate, clarithromycin, and amoxicillin for 10 to 14 days is an appropriate therapy. Posttreatment assessment of H pylori status using urea breath testing should be considered in patients with a documented history of ulcer disease or with persistent symptoms.

Original languageEnglish (US)
Pages (from-to)1285-1291
Number of pages7
JournalArchives of Internal Medicine
Volume160
Issue number9
StatePublished - May 8 2000

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Pylorus
Helicobacter pylori
Guidelines
Ulcer
Therapeutics
Marginal Zone B-Cell Lymphoma
Clarithromycin
Proton Pump Inhibitors
Dyspepsia
Amoxicillin
Gastric Mucosa
Stomach Neoplasms
Fear
Urea
Consensus
Physicians

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Peterson, W. L., Fendrick, A. M., Cave, D. R., Peura, D. A., Garabedian-Ruffalo, S. M., & Laine, L. (2000). Helicobacter pylori-related disease: Guidelines for testing and treatment. Archives of Internal Medicine, 160(9), 1285-1291.

Helicobacter pylori-related disease : Guidelines for testing and treatment. / Peterson, Walter L.; Fendrick, A. Mark; Cave, David R.; Peura, David A.; Garabedian-Ruffalo, Susan M.; Laine, Loren.

In: Archives of Internal Medicine, Vol. 160, No. 9, 08.05.2000, p. 1285-1291.

Research output: Contribution to journalArticle

Peterson, WL, Fendrick, AM, Cave, DR, Peura, DA, Garabedian-Ruffalo, SM & Laine, L 2000, 'Helicobacter pylori-related disease: Guidelines for testing and treatment', Archives of Internal Medicine, vol. 160, no. 9, pp. 1285-1291.
Peterson WL, Fendrick AM, Cave DR, Peura DA, Garabedian-Ruffalo SM, Laine L. Helicobacter pylori-related disease: Guidelines for testing and treatment. Archives of Internal Medicine. 2000 May 8;160(9):1285-1291.
Peterson, Walter L. ; Fendrick, A. Mark ; Cave, David R. ; Peura, David A. ; Garabedian-Ruffalo, Susan M. ; Laine, Loren. / Helicobacter pylori-related disease : Guidelines for testing and treatment. In: Archives of Internal Medicine. 2000 ; Vol. 160, No. 9. pp. 1285-1291.
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