Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae

D. K. Leith, E. J. Hansen, R. M. Wilson, D. C. Krause, J. B. Baseman

Research output: Contribution to journalArticle

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Abstract

A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, non cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalInfection and Immunity
Volume39
Issue number2
StatePublished - 1983

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Hemadsorption
Mycoplasma pneumoniae
Virulence
Respiratory Mucosa
Neuraminidase
Cricetinae
Lung
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Leith, D. K., Hansen, E. J., Wilson, R. M., Krause, D. C., & Baseman, J. B. (1983). Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae. Infection and Immunity, 39(2), 844-850.

Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae. / Leith, D. K.; Hansen, E. J.; Wilson, R. M.; Krause, D. C.; Baseman, J. B.

In: Infection and Immunity, Vol. 39, No. 2, 1983, p. 844-850.

Research output: Contribution to journalArticle

Leith, DK, Hansen, EJ, Wilson, RM, Krause, DC & Baseman, JB 1983, 'Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae', Infection and Immunity, vol. 39, no. 2, pp. 844-850.
Leith, D. K. ; Hansen, E. J. ; Wilson, R. M. ; Krause, D. C. ; Baseman, J. B. / Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae. In: Infection and Immunity. 1983 ; Vol. 39, No. 2. pp. 844-850.
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