Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae

D. K. Leith, E. J. Hansen, R. M. Wilson, D. C. Krause, J. B. Baseman

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A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, non cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalInfection and immunity
Issue number2
StatePublished - Mar 24 1983

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Leith, D. K., Hansen, E. J., Wilson, R. M., Krause, D. C., & Baseman, J. B. (1983). Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae. Infection and immunity, 39(2), 844-850.