Hematologic manifestations of nutritional deficiencies: Early recognition is essential to prevent serious complications

Jennifer C. Yu; Ksenya Shliakhtsitsava; Yun Zu M. Wang; Megan Paul; Lauge Farnaes; Victor Wong; Jenny Kim; Courtney D. Thornburg

doi:10.1097/MPH.0000000000001338

Hematologic manifestations of nutritional deficiencies: Early recognition is essential to prevent serious complications

Jennifer C. Yu, Ksenya Shliakhtsitsava, Yun Zu M. Wang, Megan Paul, Lauge Farnaes, Victor Wong, Jenny Kim, Courtney D. Thornburg

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Nutritional deficiencies, including deficiencies of vitamin B12, copper, and vitamin C, may result in cytopenias and hematologic symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hematologic and other manifestations. We describe 5 cases which illustrate the hematologic manifestations of nutritional deficiencies and challenges to initial diagnosis and management. Supplementation of the deficient vitamin or micronutrient in all of these cases resulted in rapid resolution of cytopenias, hemorrhage, and other associated hematologic symptoms. We also review other nutritional deficiencies that manifest with hematologic symptoms and compile recommendations on treatment and expected time to response.

Original language	English (US)
Pages (from-to)	E182-E185
Journal	Journal of Pediatric Hematology/Oncology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1097/MPH.0000000000001338
State	Published - Apr 1 2019
Externally published	Yes

Keywords

Copper
Cytopenias
Hemorrhage
Nutritional deficiencies
Vitamin B

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000001338

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title = "Hematologic manifestations of nutritional deficiencies: Early recognition is essential to prevent serious complications",

abstract = "Nutritional deficiencies, including deficiencies of vitamin B12, copper, and vitamin C, may result in cytopenias and hematologic symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hematologic and other manifestations. We describe 5 cases which illustrate the hematologic manifestations of nutritional deficiencies and challenges to initial diagnosis and management. Supplementation of the deficient vitamin or micronutrient in all of these cases resulted in rapid resolution of cytopenias, hemorrhage, and other associated hematologic symptoms. We also review other nutritional deficiencies that manifest with hematologic symptoms and compile recommendations on treatment and expected time to response.",

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T1 - Hematologic manifestations of nutritional deficiencies

T2 - Early recognition is essential to prevent serious complications

AU - Yu, Jennifer C.

AU - Shliakhtsitsava, Ksenya

AU - Wang, Yun Zu M.

AU - Paul, Megan

AU - Farnaes, Lauge

AU - Wong, Victor

AU - Kim, Jenny

AU - Thornburg, Courtney D.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Nutritional deficiencies, including deficiencies of vitamin B12, copper, and vitamin C, may result in cytopenias and hematologic symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hematologic and other manifestations. We describe 5 cases which illustrate the hematologic manifestations of nutritional deficiencies and challenges to initial diagnosis and management. Supplementation of the deficient vitamin or micronutrient in all of these cases resulted in rapid resolution of cytopenias, hemorrhage, and other associated hematologic symptoms. We also review other nutritional deficiencies that manifest with hematologic symptoms and compile recommendations on treatment and expected time to response.

AB - Nutritional deficiencies, including deficiencies of vitamin B12, copper, and vitamin C, may result in cytopenias and hematologic symptoms. Early recognition of these deficiencies is imperative for prompt treatment and improvement in hematologic and other manifestations. We describe 5 cases which illustrate the hematologic manifestations of nutritional deficiencies and challenges to initial diagnosis and management. Supplementation of the deficient vitamin or micronutrient in all of these cases resulted in rapid resolution of cytopenias, hemorrhage, and other associated hematologic symptoms. We also review other nutritional deficiencies that manifest with hematologic symptoms and compile recommendations on treatment and expected time to response.

KW - Copper

KW - Cytopenias

KW - Hemorrhage

KW - Nutritional deficiencies

KW - Vitamin B

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Hematologic manifestations of nutritional deficiencies: Early recognition is essential to prevent serious complications

Abstract

Keywords

ASJC Scopus subject areas

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