Hematological Disorders Following Bariatric Surgery

H. Qiu, R. Green, M. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Bariatric surgery is a highly effective therapy for morbidly obese patients. Roux-en-Y gastric bypass (RYGB) is usually the most common bariatric surgery procedure performed worldwide. It not only produces significant and durable weight loss, but also results in improvement of obesity-related comorbidities. However, the major problems related to this surgery are nutritional deficiencies and chronic hematological complications, like anemias pertaining to anatomical and associated physiological alteration of the gastrointestinal tract. Anemia after RYGB has been associated with insufficient intake and malabsorption of micronutrients such as iron, vitamin B12, folate, and copper concomitantly with obesity-mediated chronic inflammatory anemia. The crosstalk between chronic inflammation, immune dysregulation, and long-term sequelae of nutritional deficiency may lead to a complex suppression of normal hematopoiesis, manifested as persistent anemia only partially responsive (or nonresponsive) to nutritional supplementation. Clinical follow-up and early diagnosis are essential to allow appropriate intervention before potentially irreversible clinical manifestations occur.

Original languageEnglish (US)
Title of host publicationMetabolism and Pathophysiology of Bariatric Surgery
Subtitle of host publicationNutrition, Procedures, Outcomes and Adverse Effects
PublisherElsevier Inc.
Pages351-360
Number of pages10
ISBN (Electronic)9780128040638
ISBN (Print)9780128040119
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Anemia
  • Anemia of inflammation
  • Copper deficiency
  • Folate deficiency
  • Gastric bypass surgery
  • Iron deficiency
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Qiu, H., Green, R., & Chen, M. (2017). Hematological Disorders Following Bariatric Surgery. In Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects (pp. 351-360). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804011-9.00046-7