Hematological disorders following gastric bypass surgery

Emerging concepts of the interplay between nutritional deficiency and inflammation

Mingyi Chen, Amrita Krishnamurthy, Ali R. Mohamed, Ralph Green

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Obesity and the associated metabolic syndrome are among the most common and detrimental metabolic diseases of the modern era, affecting over 50% of the adult population in the United States. Surgeries designed to promote weight loss, known as bariatric surgery, typically involve a gastric bypass procedure and have shown high success rates for treating morbid obesity. However, following gastric bypass surgery, many patients develop chronic anemia, most commonly due to iron deficiency. Deficiencies of vitamins B1, B12, folate, A, K, D, and E and copper have also been reported after surgery. Copper deficiency can cause hematological abnormalities with or without neurological complications. Despite oral supplementation and normal serum concentrations of iron, copper, folate, and vitamin B12, some patients present with persistent anemia after surgery. The evaluation of hematologic disorders after gastric bypass surgery must take into account issues unique to the postsurgery setting that influence the development of anemia and other cytopenias. In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed.

Original languageEnglish (US)
Article number205467
JournalBioMed Research International
Volume2013
DOIs
StatePublished - Aug 20 2013

Fingerprint

Gastric Bypass
Malnutrition
Surgery
Inflammation
Anemia
Copper
Vitamin B 12
Folic Acid
Iron
Bariatric Surgery
Morbid Obesity
Thiamine
Metabolic Diseases
Weight Loss
Differential Diagnosis
Obesity
Serum
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Hematological disorders following gastric bypass surgery : Emerging concepts of the interplay between nutritional deficiency and inflammation. / Chen, Mingyi; Krishnamurthy, Amrita; Mohamed, Ali R.; Green, Ralph.

In: BioMed Research International, Vol. 2013, 205467, 20.08.2013.

Research output: Contribution to journalReview article

@article{956dfd9d014e469cb670b101d6cf090e,
title = "Hematological disorders following gastric bypass surgery: Emerging concepts of the interplay between nutritional deficiency and inflammation",
abstract = "Obesity and the associated metabolic syndrome are among the most common and detrimental metabolic diseases of the modern era, affecting over 50{\%} of the adult population in the United States. Surgeries designed to promote weight loss, known as bariatric surgery, typically involve a gastric bypass procedure and have shown high success rates for treating morbid obesity. However, following gastric bypass surgery, many patients develop chronic anemia, most commonly due to iron deficiency. Deficiencies of vitamins B1, B12, folate, A, K, D, and E and copper have also been reported after surgery. Copper deficiency can cause hematological abnormalities with or without neurological complications. Despite oral supplementation and normal serum concentrations of iron, copper, folate, and vitamin B12, some patients present with persistent anemia after surgery. The evaluation of hematologic disorders after gastric bypass surgery must take into account issues unique to the postsurgery setting that influence the development of anemia and other cytopenias. In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed.",
author = "Mingyi Chen and Amrita Krishnamurthy and Mohamed, {Ali R.} and Ralph Green",
year = "2013",
month = "8",
day = "20",
doi = "10.1155/2013/205467",
language = "English (US)",
volume = "2013",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Hematological disorders following gastric bypass surgery

T2 - Emerging concepts of the interplay between nutritional deficiency and inflammation

AU - Chen, Mingyi

AU - Krishnamurthy, Amrita

AU - Mohamed, Ali R.

AU - Green, Ralph

PY - 2013/8/20

Y1 - 2013/8/20

N2 - Obesity and the associated metabolic syndrome are among the most common and detrimental metabolic diseases of the modern era, affecting over 50% of the adult population in the United States. Surgeries designed to promote weight loss, known as bariatric surgery, typically involve a gastric bypass procedure and have shown high success rates for treating morbid obesity. However, following gastric bypass surgery, many patients develop chronic anemia, most commonly due to iron deficiency. Deficiencies of vitamins B1, B12, folate, A, K, D, and E and copper have also been reported after surgery. Copper deficiency can cause hematological abnormalities with or without neurological complications. Despite oral supplementation and normal serum concentrations of iron, copper, folate, and vitamin B12, some patients present with persistent anemia after surgery. The evaluation of hematologic disorders after gastric bypass surgery must take into account issues unique to the postsurgery setting that influence the development of anemia and other cytopenias. In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed.

AB - Obesity and the associated metabolic syndrome are among the most common and detrimental metabolic diseases of the modern era, affecting over 50% of the adult population in the United States. Surgeries designed to promote weight loss, known as bariatric surgery, typically involve a gastric bypass procedure and have shown high success rates for treating morbid obesity. However, following gastric bypass surgery, many patients develop chronic anemia, most commonly due to iron deficiency. Deficiencies of vitamins B1, B12, folate, A, K, D, and E and copper have also been reported after surgery. Copper deficiency can cause hematological abnormalities with or without neurological complications. Despite oral supplementation and normal serum concentrations of iron, copper, folate, and vitamin B12, some patients present with persistent anemia after surgery. The evaluation of hematologic disorders after gastric bypass surgery must take into account issues unique to the postsurgery setting that influence the development of anemia and other cytopenias. In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed.

UR - http://www.scopus.com/inward/record.url?scp=84881537511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881537511&partnerID=8YFLogxK

U2 - 10.1155/2013/205467

DO - 10.1155/2013/205467

M3 - Review article

VL - 2013

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 205467

ER -