Hematopoietic commitment during embryogenesis

Scott Robertson, Marion Kennedy, Gordon Keller

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Hematopoiesis develops initially as discrete blood islands in the extraembryonic yolk sac of the embryo. These blood islands consist of clusters of primitive erythrocytes surrounded by developing angioblasts that ultimately form the yolk sac vasculature. The close developmental association of these early hematopoietic and endothelial cells has led to the hypothesis that they develop from a common precursor, a cell known as the hemangioblast. Using a developmental model system based on the in vitro differentiation capacity of embyronic stem (ES) cells, we have identified a precursor with the capacity to generate endothelial as well as primitive and definitive hematopoietic progeny. The developmental potential of this precursor population suggests that it represents the in vitro equivalent of the hemangioblast.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume872
DOIs
StatePublished - Jan 1 1999

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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