Hematopoietic stem cells: Challenges to expectations

Sean J. Morrison, Douglas E. Wright, Samuel H. Cheshier, Irving L. Weissman

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalCurrent Opinion in Immunology
Volume9
Issue number2
DOIs
StatePublished - Apr 1997

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Hematopoietic Stem Cells
Yolk Sac
Cell Adhesion
Cell Biology
Cell Proliferation
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hematopoietic stem cells : Challenges to expectations. / Morrison, Sean J.; Wright, Douglas E.; Cheshier, Samuel H.; Weissman, Irving L.

In: Current Opinion in Immunology, Vol. 9, No. 2, 04.1997, p. 216-221.

Research output: Contribution to journalArticle

Morrison, Sean J. ; Wright, Douglas E. ; Cheshier, Samuel H. ; Weissman, Irving L. / Hematopoietic stem cells : Challenges to expectations. In: Current Opinion in Immunology. 1997 ; Vol. 9, No. 2. pp. 216-221.
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