Hematopoietic stem cells: Challenges to expectations

Sean J. Morrison; Douglas E. Wright; Samuel H. Cheshier; Irving L. Weissman

doi:10.1016/S0952-7915(97)80138-0

Hematopoietic stem cells: Challenges to expectations

Sean J. Morrison, Douglas E. Wright, Samuel H. Cheshier, Irving L. Weissman

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.

Original language	English (US)
Pages (from-to)	216-221
Number of pages	6
Journal	Current Opinion in Immunology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(97)80138-0
State	Published - Apr 1997

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/S0952-7915(97)80138-0

Cite this

@article{4ea882608b3e4cb691f807f960af314b,

title = "Hematopoietic stem cells: Challenges to expectations",

abstract = "The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.",

author = "Morrison, {Sean J.} and Wright, {Douglas E.} and Cheshier, {Samuel H.} and Weissman, {Irving L.}",

note = "Funding Information: Howard Hughes Medical Institute predoctoral fellow. SJM is now supported by postdoctoral fellowships from the Natural Sciences and Engineering Research Council of Canada and the Guenther Foundation. DEW is a medical student fellow of the Howard Hughes Medical Institute. SHe is supported by the Medical Scientist Training Program at Stanford University School of Medicine. The laboratoryo f ILW is supported by National Cancer Institute grant CA42551 and by a grant from SyStemix/Sandoz.",

year = "1997",

month = apr,

doi = "10.1016/S0952-7915(97)80138-0",

language = "English (US)",

volume = "9",

pages = "216--221",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Hematopoietic stem cells

T2 - Challenges to expectations

AU - Morrison, Sean J.

AU - Wright, Douglas E.

AU - Cheshier, Samuel H.

AU - Weissman, Irving L.

N1 - Funding Information: Howard Hughes Medical Institute predoctoral fellow. SJM is now supported by postdoctoral fellowships from the Natural Sciences and Engineering Research Council of Canada and the Guenther Foundation. DEW is a medical student fellow of the Howard Hughes Medical Institute. SHe is supported by the Medical Scientist Training Program at Stanford University School of Medicine. The laboratoryo f ILW is supported by National Cancer Institute grant CA42551 and by a grant from SyStemix/Sandoz.

PY - 1997/4

Y1 - 1997/4

N2 - The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.

AB - The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.

UR - http://www.scopus.com/inward/record.url?scp=0030991714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030991714&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(97)80138-0

DO - 10.1016/S0952-7915(97)80138-0

M3 - Article

C2 - 9099790

AN - SCOPUS:0030991714

SN - 0952-7915

VL - 9

SP - 216

EP - 221

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 2

ER -

Hematopoietic stem cells: Challenges to expectations

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this