Hematopoietic stem cells: Challenges to expectations

Sean J. Morrison, Douglas E. Wright, Samuel H. Cheshier, Irving L. Weissman

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalCurrent Opinion in Immunology
Volume9
Issue number2
DOIs
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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