Hemodynamic changes after pneumonectomy in the exercising foxhound

C. C W Hsia, J. I. Carlin, S. S. Cassidy, M. Ramanathan, R. L. Johnson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Pulmonary arterial pressure is higher during exercise after pneumonectomy than before. Several factors may contribute to the elevation, e.g., loss of vascular bed, overinflation of the remaining lung, and active pulmonary vasoconstriction. We measured hemodynamic changes during graded exercise in conditioned foxhounds and compared pulmonary pressure-flow relationships before and after left pneumonectomy. Pulmonary arterial pressure-flow relationship in the remaining lung is not altered by pneumonectomy, suggesting that the increase in pulmonary vascular resistance post-pneumonectomy is largely the passive consequence of increased pulmonary blood flow to the remaining lung. The potential for chronic hyperinflation of the remaining lung to increase pulmonary resistance after pneumonectomy may have been counterbalanced by a concomitant reduction in lung elastic recoil. Unexpectedly, both mean systemic blood pressure and hematocrit were higher with respect to cardiac output after pneumonectomy. Cardiac output and stroke volume at any given work load were lower after pneumonectomy than before, and heart rate response was unaltered. This pattern of responses suggests that increases in left and right ventricular afterload may have contributed to the reduction in cardiac output.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalJournal of applied physiology
Issue number1
StatePublished - 1990


  • Cardiac output
  • Exercise
  • Polycythemia
  • Pulmonary blood flow
  • Pulmonary hypertension
  • Pulmonary resistance

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Hemodynamic changes after pneumonectomy in the exercising foxhound'. Together they form a unique fingerprint.

Cite this