Hemodynamic effects of a new right ventricular assist device

E. S. Bour, C. B. Wisman, J. D. Arenas, G. A. Prophet, C. A. Miller, J. H. Donachy, J. A. Waldhausen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A right ventricular assist device (VAD) based on the principle of counterpulsation has been developed at our institution. The device is a valveless, pneumatically actuated, 40 cc, sac-type pump, with a single inlet-outlet port. For right ventricular support, the ''Uniport'' pump is anastamosed end-to-side to the pulmonary artery. In previous experimental trials, the device has been shown to impart minimal trauma to blood components. In this study, biventricular failure was induced in eight Holstein calves by normothermic ischemia during cardiopulmonary bypass. A Pierce-Donachy left VAD (LVAD) was used for left ventricular support following the ischemic insult. Hemodynamic measurements were obtained throughout the study, and each animal served as its own control. A significant increase in post injury cardiac output (33.5 ± 11.4%) was obtained with use of the Uniport and LVAD, as compared to use of the LVAD alone (p ≤ 0.005). Other hemodynamic parameters of right heart failure, including right atrial pressure (RAP), pulmonary artery pressure (PAP), and left atrial pressure (LAP) were not significantly affected. These data suggest that the Uniport right ventricular assist device significantly improves cardiac output in this model of moderate right ventricular failure. Additional studies are required, however, to optimize pump stroke volume, and to further define the performance envelope of the device.

Original languageEnglish (US)
JournalASAIO Transactions
Volume36
Issue number3
StatePublished - Jul 1990

Fingerprint

Heart-Assist Devices
Ion Transport
Hemodynamics
Atrial Pressure
Pumps
Cardiac Output
Equipment and Supplies
Pulmonary Artery
Left ventricular assist devices
Counterpulsation
Wounds and Injuries
Cardiopulmonary Bypass
Stroke Volume
Animals
Blood
Ischemia
Heart Failure
Pressure

ASJC Scopus subject areas

  • Biophysics

Cite this

Bour, E. S., Wisman, C. B., Arenas, J. D., Prophet, G. A., Miller, C. A., Donachy, J. H., & Waldhausen, J. A. (1990). Hemodynamic effects of a new right ventricular assist device. ASAIO Transactions, 36(3).

Hemodynamic effects of a new right ventricular assist device. / Bour, E. S.; Wisman, C. B.; Arenas, J. D.; Prophet, G. A.; Miller, C. A.; Donachy, J. H.; Waldhausen, J. A.

In: ASAIO Transactions, Vol. 36, No. 3, 07.1990.

Research output: Contribution to journalArticle

Bour, ES, Wisman, CB, Arenas, JD, Prophet, GA, Miller, CA, Donachy, JH & Waldhausen, JA 1990, 'Hemodynamic effects of a new right ventricular assist device', ASAIO Transactions, vol. 36, no. 3.
Bour ES, Wisman CB, Arenas JD, Prophet GA, Miller CA, Donachy JH et al. Hemodynamic effects of a new right ventricular assist device. ASAIO Transactions. 1990 Jul;36(3).
Bour, E. S. ; Wisman, C. B. ; Arenas, J. D. ; Prophet, G. A. ; Miller, C. A. ; Donachy, J. H. ; Waldhausen, J. A. / Hemodynamic effects of a new right ventricular assist device. In: ASAIO Transactions. 1990 ; Vol. 36, No. 3.
@article{5e9dd846a9684ecba0ff9be1934167ed,
title = "Hemodynamic effects of a new right ventricular assist device",
abstract = "A right ventricular assist device (VAD) based on the principle of counterpulsation has been developed at our institution. The device is a valveless, pneumatically actuated, 40 cc, sac-type pump, with a single inlet-outlet port. For right ventricular support, the ''Uniport'' pump is anastamosed end-to-side to the pulmonary artery. In previous experimental trials, the device has been shown to impart minimal trauma to blood components. In this study, biventricular failure was induced in eight Holstein calves by normothermic ischemia during cardiopulmonary bypass. A Pierce-Donachy left VAD (LVAD) was used for left ventricular support following the ischemic insult. Hemodynamic measurements were obtained throughout the study, and each animal served as its own control. A significant increase in post injury cardiac output (33.5 ± 11.4{\%}) was obtained with use of the Uniport and LVAD, as compared to use of the LVAD alone (p ≤ 0.005). Other hemodynamic parameters of right heart failure, including right atrial pressure (RAP), pulmonary artery pressure (PAP), and left atrial pressure (LAP) were not significantly affected. These data suggest that the Uniport right ventricular assist device significantly improves cardiac output in this model of moderate right ventricular failure. Additional studies are required, however, to optimize pump stroke volume, and to further define the performance envelope of the device.",
author = "Bour, {E. S.} and Wisman, {C. B.} and Arenas, {J. D.} and Prophet, {G. A.} and Miller, {C. A.} and Donachy, {J. H.} and Waldhausen, {J. A.}",
year = "1990",
month = "7",
language = "English (US)",
volume = "36",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Hemodynamic effects of a new right ventricular assist device

AU - Bour, E. S.

AU - Wisman, C. B.

AU - Arenas, J. D.

AU - Prophet, G. A.

AU - Miller, C. A.

AU - Donachy, J. H.

AU - Waldhausen, J. A.

PY - 1990/7

Y1 - 1990/7

N2 - A right ventricular assist device (VAD) based on the principle of counterpulsation has been developed at our institution. The device is a valveless, pneumatically actuated, 40 cc, sac-type pump, with a single inlet-outlet port. For right ventricular support, the ''Uniport'' pump is anastamosed end-to-side to the pulmonary artery. In previous experimental trials, the device has been shown to impart minimal trauma to blood components. In this study, biventricular failure was induced in eight Holstein calves by normothermic ischemia during cardiopulmonary bypass. A Pierce-Donachy left VAD (LVAD) was used for left ventricular support following the ischemic insult. Hemodynamic measurements were obtained throughout the study, and each animal served as its own control. A significant increase in post injury cardiac output (33.5 ± 11.4%) was obtained with use of the Uniport and LVAD, as compared to use of the LVAD alone (p ≤ 0.005). Other hemodynamic parameters of right heart failure, including right atrial pressure (RAP), pulmonary artery pressure (PAP), and left atrial pressure (LAP) were not significantly affected. These data suggest that the Uniport right ventricular assist device significantly improves cardiac output in this model of moderate right ventricular failure. Additional studies are required, however, to optimize pump stroke volume, and to further define the performance envelope of the device.

AB - A right ventricular assist device (VAD) based on the principle of counterpulsation has been developed at our institution. The device is a valveless, pneumatically actuated, 40 cc, sac-type pump, with a single inlet-outlet port. For right ventricular support, the ''Uniport'' pump is anastamosed end-to-side to the pulmonary artery. In previous experimental trials, the device has been shown to impart minimal trauma to blood components. In this study, biventricular failure was induced in eight Holstein calves by normothermic ischemia during cardiopulmonary bypass. A Pierce-Donachy left VAD (LVAD) was used for left ventricular support following the ischemic insult. Hemodynamic measurements were obtained throughout the study, and each animal served as its own control. A significant increase in post injury cardiac output (33.5 ± 11.4%) was obtained with use of the Uniport and LVAD, as compared to use of the LVAD alone (p ≤ 0.005). Other hemodynamic parameters of right heart failure, including right atrial pressure (RAP), pulmonary artery pressure (PAP), and left atrial pressure (LAP) were not significantly affected. These data suggest that the Uniport right ventricular assist device significantly improves cardiac output in this model of moderate right ventricular failure. Additional studies are required, however, to optimize pump stroke volume, and to further define the performance envelope of the device.

UR - http://www.scopus.com/inward/record.url?scp=0025457145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025457145&partnerID=8YFLogxK

M3 - Article

VL - 36

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 3

ER -