Hemodynamic effects of superior mesenteric arterial and intravenous vasopressin infusions in patients with portal hypertension

S. L. Kaufman, W. C. Maddrey, D. P. Harrington, R. I. White

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Administration of vasopressin (0.4 units/minute) via the superior mesenteric artery (SMA) resulted in a mean 25% reduction in corrected hepatic venous wedge pressure (CHWP) in 9 stable non-bleeding patients with cirrhosis and portal hypertension. There was wide variation of response in individual patients with two of nine showing no decrease in CHWP to vasopressin. Selective intra-arterial infusion did not protect against the systemic effects of vasopressin and resulted in significant elevations in blood pressure (21%) and systemic vascular resistance (39%). A slight decrease in cardiac output (11%) was also observed. In 6 of these patients, vasopressin (0.4 units/minute) was also given intravenously. The resultant decreases in CHWP were similar to those observed with SMA administration.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalInvestigative Radiology
Volume12
Issue number3
DOIs
StatePublished - Jan 1 1977

Keywords

  • Hemodynamics
  • Portal hypertension
  • Superior mesenteric artery
  • Vasopressin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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