Hemodynamic effects of superior mesenteric arterial and intravenous vasopressin infusions in patients with portal hypertension

S. L. Kaufman, W. C. Maddrey, D. P. Harrington, R. I. White

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Administration of vasopressin (0.4 units/minute) via the superior mesenteric artery (SMA) resulted in a mean 25% reduction in corrected hepatic venous wedge pressure (CHWP) in 9 stable non-bleeding patients with cirrhosis and portal hypertension. There was wide variation of response in individual patients with two of nine showing no decrease in CHWP to vasopressin. Selective intra-arterial infusion did not protect against the systemic effects of vasopressin and resulted in significant elevations in blood pressure (21%) and systemic vascular resistance (39%). A slight decrease in cardiac output (11%) was also observed. In 6 of these patients, vasopressin (0.4 units/minute) was also given intravenously. The resultant decreases in CHWP were similar to those observed with SMA administration.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalInvestigative Radiology
Volume12
Issue number3
StatePublished - 1977

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Portal Hypertension
Vasopressins
Intravenous Infusions
Pulmonary Wedge Pressure
Venous Pressure
Hemodynamics
Superior Mesenteric Artery
Liver
Intra Arterial Infusions
Cardiac Output
Vascular Resistance
Fibrosis
Blood Pressure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hemodynamic effects of superior mesenteric arterial and intravenous vasopressin infusions in patients with portal hypertension. / Kaufman, S. L.; Maddrey, W. C.; Harrington, D. P.; White, R. I.

In: Investigative Radiology, Vol. 12, No. 3, 1977, p. 210-214.

Research output: Contribution to journalArticle

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