Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor

Bharat B. Biswal, Sridhar S. Kannurpatti, Bart Rypma

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Functional magnetic resonance imaging blood-oxygenation-level-dependent (fMRI-BOLD) signal representing neural activity may be optimized by discriminating MR signal components related to neural activity and those related to intrinsic properties of the cortical vasculature. The objective of this study was to reduce the hemodynamic change independent of neural activity to obtain a scaled fMRI-BOLD response using two factors, namely, low-frequency spectral amplitude (LFSA) and breath-hold amplitude (BHA). Ten subjects (age range, 22-38 years) were scanned during four task conditions: (a) rest while breathing room air, (b) bilateral finger tapping while breathing room air, (c) rest during a partial inspirational breath-hold, and (d) rest during moderate hypercapnia (breathing 5% CO2, 20% O2 and 75% N2). In all subjects who breathed 5% CO2, regions with significant BOLD response during breath-hold correlated significantly with the percent signal increase during 5% CO2 inhalation. Finger-tapping-induced responses in the motor cortex were diminished to a similar extent after scaling using either LFSA or BHA. Inter- and intrasubject variation in the amplitude of the BOLD signal response reduced after hemodynamic scaling using LFSA or BHA. The results validated the hemodynamic amplitude scaling using LFSA with the earlier established BHA. LFSA free from motor-task contamination can be used to calibrate the fMRI-BOLD response in lieu of BHA or hypercapnia to minimize intra- and intersubject variation arising from vascular anatomy and vasodilative capacity.

Original languageEnglish (US)
Pages (from-to)1358-1369
Number of pages12
JournalMagnetic Resonance Imaging
Volume25
Issue number10
DOIs
StatePublished - Dec 2007

Fingerprint

hemodynamics
Oxygenation
oxygenation
Hemodynamics
blood
magnetic resonance
Scalability
Respiration
Blood
Hypercapnia
Magnetic Resonance Imaging
low frequencies
scaling
Fingers
Air
Motor Cortex
Inhalation
Blood Vessels
hypercapnia
Anatomy

Keywords

  • BOLD
  • Breath-hold
  • CBF
  • fMRI
  • Hypercapnia
  • Low frequency
  • Scaling
  • Spectral amplitude

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Hemodynamic scaling of fMRI-BOLD signal : validation of low-frequency spectral amplitude as a scalability factor. / Biswal, Bharat B.; Kannurpatti, Sridhar S.; Rypma, Bart.

In: Magnetic Resonance Imaging, Vol. 25, No. 10, 12.2007, p. 1358-1369.

Research output: Contribution to journalArticle

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