Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

Masao Yoshizumi, Hiroki Kurihara, Takao Sugiyama, Fumimaro Takaku, Masashi Yanagisawa, Tomoh Masaki, Yoshio Yazaki

Research output: Contribution to journalArticle

441 Scopus citations


We have examined the effect of shear stress on the production of endothelin by cultured porcine endothelial cells. Low shear stress stimulated the expression of endothelin mRNA in polygonal endothelial cells with a peak time of 2 to 4 hours and also increased the release of immunoreactive endothelin into the culture medium. The expression of endothelin mRNA in the ellipsoidal endothelial cells under higher shear stress was not different from that of the control level. Our results suggest a possible role for hemodynamic shear stress in the regulation of endothelin production in vascular endothelial cells.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jun 15 1989


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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