Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans

Paula Y S Poh, Daniel Gagnon, Steven A. Romero, Victor A. Convertino, Beverley Adams-Huet, Craig G. Crandall

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

ABSTRACT: One in 10 deaths worldwide is caused by traumatic injury, and 30–40% of those trauma-related deaths are due to hemorrhage. Currently, warming a bleeding victim is the standard of care due to the adverse effects of combined hemorrhage and hypothermia on survival. We tested the hypothesis that heating is detrimental to the maintenance of arterial pressure and cerebral perfusion during hemorrhage, while cooling is beneficial to victims who are otherwise normothermic. Twenty-one men (31?±?9 y) were examined under 2 separate protocols designed to produce central hypovolemia similar to hemorrhage. Following 15?min of supine rest, 10?min of 30 mmHg of lower body negative pressure (LBNP) was applied. On separate randomized days, subjects were then exposed to skin surface cooling (COOL), warming (WARM) or remained thermoneutral (NEUT), while LBNP continued. Subjects remained in these thermal conditions for either 40?min of 30 mmHg LBNP (N?=?9), or underwent a continuous LBNP ramp until hemodynamic decompensation (N?=?12). Arterial blood pressure during LBNP was dependent on the thermal perturbation as blood pressure was greater during COOL (P?>?0.001) relative to NEUT and WARM for both protocols. Middle cerebral artery blood velocity decreased (P?

Original languageEnglish (US)
JournalShock
DOIs
StateAccepted/In press - May 24 2016

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Lower Body Negative Pressure
Hemodynamics
Hemorrhage
Arterial Pressure
Hot Temperature
Architectural Accessibility
Hypovolemia
Middle Cerebral Artery
Wounds and Injuries
Standard of Care
Hypothermia
Heating
Perfusion
Maintenance
Blood Pressure
Skin
Survival

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans. / Poh, Paula Y S; Gagnon, Daniel; Romero, Steven A.; Convertino, Victor A.; Adams-Huet, Beverley; Crandall, Craig G.

In: Shock, 24.05.2016.

Research output: Contribution to journalArticle

Poh, Paula Y S ; Gagnon, Daniel ; Romero, Steven A. ; Convertino, Victor A. ; Adams-Huet, Beverley ; Crandall, Craig G. / Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans. In: Shock. 2016.
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