Henoch-Schönlein purpura in a child with hyperimmunoglobulinemia D and periodic fever syndrome

Jonathan E. Wickiser, Frank T. Saulsbury

Research output: Contribution to journalArticle

13 Scopus citations


This report describes a 3-year-old girl with a long history of periodic fever who presented with Henoch-Schönlein purpura. She was diagnosed with hyperimmunoglobulinemia D and periodic fever syndrome by means of mutation analysis of the mevalonate kinase gene. The serum IgA concentration was markedly elevated, but the serum IgD concentration was normal. This report emphasizes that Henoch-Schönlein purpura may be an important clinical feature of hyperimmunoglobulinemia D and periodic fever syndrome, in addition, this syndrome should be considered in patients with Henoch-Schönlein purpura in whom there is a history of recurrent fevers, even when the serum IgD concentration is normal.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalPediatric dermatology
Issue number2
StatePublished - Mar 1 2005


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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