Heparin-binding. EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis

H. T. Nguyen, S. H. Bride, A. B. Badawy, R. M. Adam, J. Lin, A. Orsola, P. D. Guthrie, M. R. Freeman, Craig A Peters

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The expression of certain growth factors in the epidermal growth factor (EGF) family is altered in response to renal injury. Recent studies have demonstrated that heparin binding EGF-like growth factor (HB-EGF) expression may be cytoprotective in response to apoptotic signals. The purpose of tiffs study was to investigate the potential role of HB-EGF in the upper urinary tract following unilateral ureteral obstruction. We present evidence that: i) ureteral obstruction induced cell-specific but transient activation of HB-EGF gene expression; ii) HB-EGF expression in renal epithelial cells increased under conditions where mechanical deformation, such as that caused by hydronephrotic distension, induces apoptosis, but HB-EGF expression did not increase in renal pelvis smooth muscle cells under identical conditions; and iii) enforced expression of HB-EGF served to protect renal epithelial cells from stretch-induced apoptosis. These results suggest a potential mechanism by which the kidney protects itself from apoptosis triggered by urinary tract obstruction.

Original languageEnglish (US)
Pages (from-to)889-898
Number of pages10
JournalAmerican Journal of Pathology
Volume156
Issue number3
DOIs
StatePublished - Jan 1 2000

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Epidermal Growth Factor
Heparin
Intercellular Signaling Peptides and Proteins
Apoptosis
Kidney
Ureteral Obstruction
Urinary Tract
Epithelial Cells
Kidney Pelvis
Smooth Muscle Myocytes
Heparin-binding EGF-like Growth Factor
Gene Expression
Wounds and Injuries

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Heparin-binding. EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. / Nguyen, H. T.; Bride, S. H.; Badawy, A. B.; Adam, R. M.; Lin, J.; Orsola, A.; Guthrie, P. D.; Freeman, M. R.; Peters, Craig A.

In: American Journal of Pathology, Vol. 156, No. 3, 01.01.2000, p. 889-898.

Research output: Contribution to journalArticle

Nguyen, H. T. ; Bride, S. H. ; Badawy, A. B. ; Adam, R. M. ; Lin, J. ; Orsola, A. ; Guthrie, P. D. ; Freeman, M. R. ; Peters, Craig A. / Heparin-binding. EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. In: American Journal of Pathology. 2000 ; Vol. 156, No. 3. pp. 889-898.
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AU - Adam, R. M.

AU - Lin, J.

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AU - Guthrie, P. D.

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