Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia

Willis C. Maddrey, Julio O. Cukier, Apolo C. Maglalang, John K. Boitnott, Gerard B. Odell

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P < 0.005) than in 14 nonjaundiced comparison patients without liver disease. The elevated UDP-glucuronyltransferase activity in sickle cell anemia was similar to that found in 10 patients who chronically ingested drugs (barbiturates or estrogens) known to increase UDP-glucuronyltransferase activity. These obseverations suggest enhanced conjugation of bilirubin in patients with sickle cell anemia may result from substrate (bilirubin) induction of UDP-glycuronyltransferase.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalGastroenterology
Volume74
Issue number2 PART 1
StatePublished - 1978

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Glucuronosyltransferase
Sickle Cell Anemia
Uridine Diphosphate
Bilirubin
Liver
Barbiturates
Enzymes
Liver Diseases
Estrogens
Erythrocytes
Biopsy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Maddrey, W. C., Cukier, J. O., Maglalang, A. C., Boitnott, J. K., & Odell, G. B. (1978). Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia. Gastroenterology, 74(2 PART 1), 193-195.

Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia. / Maddrey, Willis C.; Cukier, Julio O.; Maglalang, Apolo C.; Boitnott, John K.; Odell, Gerard B.

In: Gastroenterology, Vol. 74, No. 2 PART 1, 1978, p. 193-195.

Research output: Contribution to journalArticle

Maddrey, WC, Cukier, JO, Maglalang, AC, Boitnott, JK & Odell, GB 1978, 'Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia', Gastroenterology, vol. 74, no. 2 PART 1, pp. 193-195.
Maddrey WC, Cukier JO, Maglalang AC, Boitnott JK, Odell GB. Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia. Gastroenterology. 1978;74(2 PART 1):193-195.
Maddrey, Willis C. ; Cukier, Julio O. ; Maglalang, Apolo C. ; Boitnott, John K. ; Odell, Gerard B. / Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia. In: Gastroenterology. 1978 ; Vol. 74, No. 2 PART 1. pp. 193-195.
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