Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

Shireesha Sankella; Abhimanyu Garg; Jay D. Horton; Anil K. Agarwal

doi:10.1074/jbc.M113.530998

Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2^-/- mice

Shireesha Sankella, Abhimanyu Garg, Jay D. Horton, Anil K. Agarwal

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Abstract

Background: Lipodystrophic Agpat2^-/- mice are severely diabetic and insulin resistant. Results: Livers of Agpat2^-/- mice have elevated levels of phosphatidic acids (PAs), which enhance gluconeogenesis. Conclusion: PA enhanced hepatic gluconeogenesis contributes to the hyperglycemia present in Agpat2^-/- mice. Significance: PA enhanced hepatic gluconeogenesis might have wider implications in understanding the development of hyperglycemia in type 2 diabetes.

Original language	English (US)
Pages (from-to)	4762-4777
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.530998
State	Published - Feb 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Lipodystrophic Agpat2-/- mice are severely diabetic and insulin resistant. Results: Livers of Agpat2-/- mice have elevated levels of phosphatidic acids (PAs), which enhance gluconeogenesis. Conclusion: PA enhanced hepatic gluconeogenesis contributes to the hyperglycemia present in Agpat2-/- mice. Significance: PA enhanced hepatic gluconeogenesis might have wider implications in understanding the development of hyperglycemia in type 2 diabetes.",

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AU - Horton, Jay D.

AU - Agarwal, Anil K.

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AB - Background: Lipodystrophic Agpat2-/- mice are severely diabetic and insulin resistant. Results: Livers of Agpat2-/- mice have elevated levels of phosphatidic acids (PAs), which enhance gluconeogenesis. Conclusion: PA enhanced hepatic gluconeogenesis contributes to the hyperglycemia present in Agpat2-/- mice. Significance: PA enhanced hepatic gluconeogenesis might have wider implications in understanding the development of hyperglycemia in type 2 diabetes.

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Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2^-/- mice

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