Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

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Abstract

Background: Lipodystrophic Agpat2-/- mice are severely diabetic and insulin resistant. Results: Livers of Agpat2-/- mice have elevated levels of phosphatidic acids (PAs), which enhance gluconeogenesis. Conclusion: PA enhanced hepatic gluconeogenesis contributes to the hyperglycemia present in Agpat2-/- mice. Significance: PA enhanced hepatic gluconeogenesis might have wider implications in understanding the development of hyperglycemia in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)4762-4777
Number of pages16
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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