Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy

M. S. Huberman, P. A. Bunn, M. J. Matthews, D. C. Ihde, A. F. Gazdar, M. H. Cohen, J. D. Minna

Research output: Contribution to journalArticle

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Abstract

Forty-three patients with cutaneous T-cell lymphomas (mycosis fungoides and the Sezary syndrome) underwent routine staging procedures to assess extent of disease prior to therapy. Evaluation of the liver included physical examination, liver function tests, 99mTc-liver-spleen scans, percutaneous liver biopsy, and peritoneoscopy with multiple liver biopsies. Seven patients (16%) had biopsy-documented hepatic lymphoma, histologically defined as focal aggregates of atypical convoluted visceral site. Involvement of peripheral blood, leukocytosis, and generalized erythroderma were significantly associated with hepatic lymphoma. Biopsy examination was the only accurate method of detecting hepatic involvement, and peritoneoscopy with multiple biopsies appeared to be more sensitive than a single percutaneous biopsy, since the yield of positive biopsies increased from three to seven. In order to better understand the natural history of the cutaneous T-cell lymphomas and the relation of hepatic involvement to survival, histologic evaluation of the liver in patients with the cutaneous lymphomas should be carried out prior to therapy.

Original languageEnglish (US)
Pages (from-to)1683-1688
Number of pages6
JournalCancer
Volume45
Issue number7
StatePublished - 1980

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Cutaneous T-Cell Lymphoma
Laparoscopy
Biopsy
Liver
Lymphoma
Sezary Syndrome
Exfoliative Dermatitis
Mycosis Fungoides
Liver Function Tests
Leukocytosis
Physical Examination
Spleen
Skin
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Huberman, M. S., Bunn, P. A., Matthews, M. J., Ihde, D. C., Gazdar, A. F., Cohen, M. H., & Minna, J. D. (1980). Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy. Cancer, 45(7), 1683-1688.

Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy. / Huberman, M. S.; Bunn, P. A.; Matthews, M. J.; Ihde, D. C.; Gazdar, A. F.; Cohen, M. H.; Minna, J. D.

In: Cancer, Vol. 45, No. 7, 1980, p. 1683-1688.

Research output: Contribution to journalArticle

Huberman, MS, Bunn, PA, Matthews, MJ, Ihde, DC, Gazdar, AF, Cohen, MH & Minna, JD 1980, 'Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy', Cancer, vol. 45, no. 7, pp. 1683-1688.
Huberman MS, Bunn PA, Matthews MJ, Ihde DC, Gazdar AF, Cohen MH et al. Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy. Cancer. 1980;45(7):1683-1688.
Huberman, M. S. ; Bunn, P. A. ; Matthews, M. J. ; Ihde, D. C. ; Gazdar, A. F. ; Cohen, M. H. ; Minna, J. D. / Hepatic involvement in the cutaneous T-cell lymphomas. Results of percutaneous biopsy and peritoneoscopy. In: Cancer. 1980 ; Vol. 45, No. 7. pp. 1683-1688.
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